Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous adipose (SA) tissue between obese rats with and without type 2 diabetes (T2D) and its response to resistance training in T2D. Materials and Methods: 21 male wistar rats (220±20 g...

Aims: Obesity is associated with cardiovascular disease. Today, changing childhood lifestyle may affect on cardiovascular diseases factors. The goal of this research was to determine the evaluation of changes in lipid profiles, insulin resistance and serum FGF21 following three types of exercise training in sedentary obese children. Materials and Methods: Sixty obese boys 8-12 years old with z...

risk of premature mortality and cardiovascular disease in people with diabetes are twice that of non-diabetics, but the role of inflammatory biomarkers such as resistin and crp that used for prediction of these disease is unknown after exercise. so, the aim of the present study was to examine the proinflammatory role of resistin and crp, after aerobic and resistance exercise in patients with ty...

Objective: Resistance exercise is recommended as effective treatments for people with type 2 diabetes. However, the impact of this mode of exercise on blood glucose, insulin and insulin resistance in Iranian's type 2 diabetic patients is unclear. We conducted a systematic review of the literature for the effect of resistance exercise training on these clinical markers in Iranian's type 2 diabet...

Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ ...

OBJECTIVE Physical activity or metformin enhances insulin sensitivity and opposes the progression from prediabetes to type 2 diabetes. The combination may be more effective because each treatment stimulates AMP-activated protein kinase activity in skeletal muscle. We evaluated the effects of exercise training plus metformin on insulin sensitivity in men and women with prediabetes, compared with...

Introduction: Myostatin regulates skeletal muscle mass and adipogenesis, but serum response to continuous and discontinuous exercises training it has not been studied in menopause and menstrual groups of women. The purpose of this study was to investigate the serum response of myostatin, insulin and glucose to use four different aerobic exercises training in menopause and menstrual groups of wo...