background: although effects of trace elements on secretion of sex steroids and insulin have been studied, the effects of these hormones on serum level of trace elements have been rarely investigated. the aim of the present study was to evaluate the effect of testosterone and finasteride administration and castration on serum levels of testosterone, insulin, zinc and chromium. methods: male adu...

objective: as the aqueous extract of capparis spinosa (cs) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of cs in diabetic mice.materials and methods: both single and repeated oral administrations of aqueous extract of cs were performed in multi-low dose streptozotocin-induced (mlds) diabetic mice. euglycemic hyperinsulinemic clamp was used in as...

background: hyperglycemia is one of the important featurs of diabetes. in cell culture studies different methods are used to mimic the hyperglycemia condition. in this study we investigate response of human liver cancer cell line (hepg2) to high insulin, high glucose, and high insulin/ high glucose medium exposure. methods: hepg2 cells were settled in dmem+0.1% fbs or dmem free-serum medium wit...

conclusions metabolic abnormalities in bscl may prove fatal necessitating optimal therapeutic and preventive measures. patients are advised low fat diet with enhanced physical activities. other treatments include metformin, n-3 polyunsaturated fatty acids and leptin replacement for correction of metabolic complications. we report this case of bscl in view of its rarity. case presentation an 18 ...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

background: the correlation of metabolic syndrome and migraine headache was evaluated in some previous studies. however there is no study that compared the prevalence of metabolic syndrome in the patients with and without migraine. control of coincidental factors such as metabolic syndrome reduces therapeutic resistance in migrainous patients. the aim of this study was to compare prevalence of ...

background evidence indicates that insulin resistance results in poor sustained viral response (svr) in patients with chronic hepatitis c (chc). metformin is an oral hypoglycemic agent which improves insulin resistance. methods we sought to determine if the addition of metformin to the treatment regimen could improve svr in treatment-naive chc patients in a randomized, double-blind, placebo-con...

background: use of glucosamine as an alternative treatment for osteoarthritis is becoming more frequent, including in those who have diabetes at the same time. the results from in vitro and animal studies propose that glucosamine may inversely affect glucose metabolism. however, the recommended dose of oral glucosamine in healthy people or diabetics did not have such effects consistently. the a...

Introduction: Endothelium and smooth muscle dysfunction are the most important complications of diabetes. In type 1 diabetic patients, absence of insulin leads to vasoconstriction and lower skin blood perfusion. Release of some mediators by endothelium which is induced by insulin causes vasodilation, but the exact mechanism of insulin vasodilatory effect is not detected properly. At present st...

OBJECTIVE: Hyperglycemia is associated with increased morbidity and mortality in diabetic patients following coronary artery bypass grafting. Tight glycemic control in perioperative period can reduce these events. The goal of this study was to determine whether combination of continuous infusion and subcutaneous glargine as a basal insulin could improve glycemic control. MATERIAL AND METHODS:...