We evaluated the usefulness and limitations of praecordial ST segment mapping as a clinical means of assessing the size of acute myocardial infarction in 14 patients with anterior myocardial infarction and 13 patients with inferior myocardial infarction. sigma ST, the sum of ST segment elevations, and nST, the number of leads showing ST segment elevation, were obtained from serial electrocardio...

We have examined the incidence and size of infarction after occlusion of different portions of the rat middle cerebral artery (MCA) in order to define the reliability and predictability of this model of brain ischemia. We developed a neurologic examination and have correlated changes in neurologic status with the size and location of areas of infarction. The MCA was surgically occluded at diffe...

Clinical and hemodynamic manifestations of overt right ventricular infarction differ markedly from those that involve injury confined exclusively to the left ventricle. However, the frequency of covert right ventricular infarction and its influence on overall enzymatically estimated infarct size, hemodynamics and prognosis have not been characterized. Accordingly, 249 patients with transmural a...

Clinical and hemodynamic manifestations of overt right ventricular infarction differ markedly from those that involve injury confined exclusively to the left ventricle. However, the frequency of covert right ventricular infarction and its influence on overall enzymatically estimated infarct size, hemodynamics and prognosis have not been characterized. Accordingly, 249 patients with transmural a...

We studied 89 patients with first time myocardial infarction and treated with primary PCI. There was only a weak correlation between ischemia duration and final myocardial scar size measured with ceMRI six weeks later. Other factors like anterior infarction, a patent artery pre-PCI and effects of reperfusion injury may have had greater influence on infarct size than time-totreatment per se.

To study the variability of the fraction of CPK released from the infarcted heart which enters the serum (serum entry ratio, or SER) with size and model of infarction, nine dogs underwent homogeneous infarctions (LAD ligation) of varying sizes, and 10 dogs underwent scattered infarctions (left coronary embolization). In homogeneous infarcts there was an inverse linear relationship of SER to inf...

Background. Mortality from acute myocardial infarction with ST-segment elevation in cardiac hospitals ranges 4.5 to 7 %, and these data has not decreased recent years. The most common cause of death patients is cardiogenic shock, the likelihood which directly depends on infarct size. It quite clear that there an urgent need create drugs limit size prevent occurrence shock. aim. To evaluate role...

Hypothermia has proven to be one of the most potent and consistent adjunctive therapies for infarct size reduction in numerous preclinical studies, when administered prior to reperfusion. The mechanisms leading to protection are multifactorial. Early clinical trials failed to demonstrate a decrease in infarct size, likely due to the difficulty in achieving adequate cooling prior to reperfusion....

OBJECTIVES The objective of this study was to investigate whether strain Doppler echocardiography performed immediately after revascularization by percutaneous coronary intervention could predict the extent of myocardial scar, determined by contrast-enhanced magnetic resonance imaging (MRI). BACKGROUND There is considerable variability in survival rate after percutaneous coronary intervention...