Context: Hyperbilirubinemia is a common cause for diagnostic work-up and therapeutic intervention in neonates needs convenient, quick, safe treatment modality. Phototherapy the most neonatal jaundice; however, complementary still needed. Despite identification of enzymatic pathways bilirubin catabolism, few pharmacological interventions have been found to be effective reducing bilirubin, along ...

Cholestasis in early infancy represents a diagnostic dilemma and most of these infants suffer either from extrahepatic biliary atresia or idiopathic neonatal hepatitis. Differentiation between the two conditions may be extremely difficult both clinically and biochemically, and a diagnostic liver biopsy is usually required. We report on a Sudanese infant who presented at the age of 4 weeks with ...

A six-week-old male infant was admitted for investigation of cholestasis and pale stools. He became lethargic and apnoeic with prolonged seizures after a percutaneous liver biopsy. Subsequent investigations showed conjugated hyperbilirubinaemia, elevated liver enzymes, and hypoglycaemia. The radinuclide hepatobiliary scintigraphy was non-excretory. After an operative cholangiogram, the infant d...

OBJECTIVES To further explore the relationship of early newborn hospital discharge and readmission for jaundice, and to determine if early hospital discharge was associated with increased severity of jaundice among those readmitted. METHODS We performed a population-based case-control study using Washington State vital statistics, birth certificates, and hospital discharge abstracts from 1991...

Bile-plug syndrome is defined as an obstruction of the common bile duct by bile sludge in full-term infants. It is a correctable cause of obstructive jaundice in infants and is generally treated surgically. Here, we present a case of a 5-month-old infant with bile-plug syndrome, which was treated by percutaneous biliary interventions. To the best of our knowledge, percutaneous treatment of bile...

PURPOSE The aim of this study was to evaluate the usefulness of magnetic resonance cholangiography (MRC) for the diagnosis of biliary atresia in infantile cholestatic jaundice. METHODS Forty-seven consecutive infants with cholestatic jaundice underwent single-shot MRC. The diagnosis of biliary atresia was made by MRC based on the nonvisualization of extrahepatic bile ducts and excluded on the...

Ever since Yllp0 published his valuable contribution to the subject of icterus neonatorum in 1913, it has seemed almost certain that the liver of the newborn infant is far less efficient than that of the adult in excreting bile pigment. Nevertheless very few direct studies of the excretory capacity of the liver of the newborh infant have been made, and the work reported here was carried out in ...

BACKGROUND Delay in the presentation of infants with jaundice at the hospital is a reason for the persistence of the severe forms of jaundice. OBJECTIVE The aim was to determine the influence of maternal knowledge on newborn jaundice on their care-seeking practices. METHODS In a cross-sectional survey, mothers whose infants presented with significant hyperbilirubinemia were assessed for kno...

OBJECTIVE To determine how well parents, nurses, physicians, and an Ingram icterometer can detect the presence and the severity of jaundice in newborns. SETTING Normal newborn nursery in a 340-bed teaching hospital. PATIENTS OR OTHER PARTICIPANTS Nurses and physicians caring for nursery infants and parents of the infants. INTERVENTIONS Physicians and nurses examining newborns documented w...