نتایج جستجو برای: inducible nitric oxide
تعداد نتایج: 218338 فیلتر نتایج به سال:
inducible nitric oxide synthase (inos) gene expresses a calcium calmudolin-independent enzyme which can catalyse no production from l-arginine. the induction of inos activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (lps). previous studies indicated that all nitric oxide synthases (nos) activated in human umbilical vein endot...
Background & Aims: The activity of nitric oxide synthase was assayed in enterocytes isolated from human duodenal biopsies to determine its role in celiac disease. Patients were categorized into those with irritable bowel syndrome, iron deficiency anemia, B12/folate deficiency and treated and untreated celiac disease. Methods & Results: Enterocytes isolated from all groups showed 1400W-inhibitab...
During glomerular inflammation mesangial cells are the major source and target of nitric oxide that pro-foundly influences proliferation, adhesion, and death of mesangial cells. The effect of nitric oxide on the mRNA expression pattern of cultured rat mesangial cells was therefore investigated by RNA-arbitrarily-primed polymerase chain reaction. Employing this approach, biglycan expression turn...
In cystic fibrosis (CF), low concentrations of exhaled nitric oxide (NO) and reduced expression of inducible nitric oxide synthase (iNOS) in airway epithelium have been reported. However, abundant iNOS expression has been found in the subepithelial tissues and elevated concentrations of NO metabolites in breath condensate and sputum. These conflicting results may be explained by increased scave...
BACKGROUND Recent evidence suggests that nitric oxide produced via the neuronal nitric oxide synthase is involved mainly in the early response to sepsis, whereas nitric oxide derived from the inducible nitric oxide synthase is responsible during the later phase. We hypothesized that early neuronal and delayed inducible nitric oxide synthase blockade attenuates multiple organ dysfunctions during...
MRL-I/r/I/r mice spontaneously develop various manifestations of autoimmunity indnding an inflammatory arthropathy and immune complex glomerulonephritis. This study examines the role of nitric oxide, a molecule with proinfhmmatory actions, in the pathogenesis of MRL1/r/I/r autoimmune disease. MRL-I/r/I/r mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production) t...
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