نتایج جستجو برای: induced thrombosis
تعداد نتایج: 1027956 فیلتر نتایج به سال:
Heme oxygenase (HO)-1 (encoded by Hmox1) catalyzes the oxidative degradation of heme to biliverdin and carbon monoxide. HO-1 is induced during inflammation and oxidative stress to protect tissues from oxidative damage. Because intravascular thrombosis forms at sites of tissue inflammation, we hypothesized that HO-1 protects against arterial thrombosis during oxidant stress. To investigate the d...
Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We raised plasma fibrinogen levels in mice via intravenous infusion and induced thr...
background: antiphospholipid antibodies (apl) are a heterogeneous family of anti-bodies associated with thrombosis and other complications. objective: to study the prevalence of apl in patients with thrombosis at aleppo university hospitals, syria. methods: one hundred and fifty-seven patients with venous and arterial thrombosis and 63 healthy controls were studied. anticardiolipin antibodies (...
Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.
Epidemiologic studies have correlated elevated plasma fibrinogen (hyperfibrinogenemia) with risk of cardiovascular disease and arterial and venous thrombosis. However, it is unknown whether hyperfibrinogenemia is merely a biomarker of the proinflammatory disease state or is a causative mechanism in the etiology. We raised plasma fibrinogen levels in mice via intravenous infusion and induced thr...
Background: It is well recognized that a hypercoagulable state exists when a person is exposed to high altitude environment. This may manifest as early thromboembolic episodes, which result in acute pulmonary embolism. On further exposure to high-altitude environment, the ongoing thrombogenesis has been implicated in the causation of subacute mountain sickness. Only anecdotal reports of deep ve...
anticardiolipin antibody in patients with behçet's disease with and without vascular thrombosis
objective: the clinical value of igg anticardiolipin antibody in patients with behçet's disease with or without vascular thrombosis was evaluated. methods: igg isotype of anticardiolipin (acl) antibody was assessed in 40 behçet's disease (bd) patients with venous or arterial thrombosis, 40 bd patients without venous or arterial thrombosis and 80 healthy subjects as controls. the lev...
The recent observation that knock-out of protease-activated receptor-4 (PAR4) ablates thrombin signaling in mouse platelets and protects against ferric chloride– induced thrombosis of mouse mesenteric arterioles suggests that thrombin’s actions on platelets can play an important role in thrombosis. Complete ablation of thrombin signaling would be difficult to achieve in human beings because hum...
AIMS Medical treatment of arterial thrombosis is mainly directed against platelets and coagulation factors, and can lead to bleeding complications. Novel antithrombotic therapies targeting immune cells and neutrophil extracellular traps (NETs) are currently being investigated in animals. We addressed whether immune cell composition of arterial thrombi induced in mouse models of thrombosis resem...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only w...
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