نتایج جستجو برای: induced pain
تعداد نتایج: 1208434 فیلتر نتایج به سال:
Background and Objective: GABAergic inhibitory interneurons are distributed in spinal cord for pain sensation, so that muscimol and bicuculline (GABAA agonist and antagonist) reduces and enhances pain, respectively. Gap junctions (Gj) are membrane contacts for exchanging the signaling agents and small metabolites. Using spinal administration (i.t) of carbenoxolone (Gj blockers), this stud...
background: organic nitrates relax all kinds of smooth muscle , not only vascular smooth muscle , a fact that has allowed the use of these drugs to treat many different aliments. objective.-the purpuse of this study was to examine prosepectively benefical effects , if any, of sublingual nitroglycerin on the pain of renal colic. design.- prospective , randomised , double blind, placebo- contoled...
Background and purpose : Dextromethorphan is a non-competitive NMDÂ receptor antagonist in the glutamatergic system with over 47 years of clinical usage experience as an over-the counter antitussive drug. We previously demonstrated that dextromethorphan modulates the pain threshold in the mouse acetic acid (0.6%,intraperitonealy)-induced writhing test (a tonic and chemical model for chronic p...
Introduction: It is known that acute and chronic stress induce hormonal and neuronal changes which affecting both pain threshold and nociceptive behaviours. Orexin plays an important role in modulation of pain and stress. Considering pain modulation during stress and the role of orexin in pain and stress, orexin might be involved in pain modulation during stress.We evaluated the involvement ...
antinociceptive effects, acute toxicity and chemical composition of vitex agnus-castus essential oil
objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materi...
introduction: estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (lc). estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and gabaa receptors. lc is involved in noradrenergic descending pain modulation. methods: in order to study the effect of 17β-estradio...
effects of crocin and safranal, saffron constituents, on the formalin-induced orofacial pain in rats
objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...
Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as wel...
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