Keratinocyte migration, the initial event and rate-limiting step in wound healing, plays a vital role in restoration of the intact skin barrier, also known as re-epithelialization. After acute tissue injury, hypoxic microenvironment gradually develops and acts as an early stimulus to initiate the healing process. Although we have previously found that hypoxia induces keratinocyte migration, the...

Breast and prostate cancers preferentially metastasise to bone tissue, with metastatic lesions forming in the skeletons of most patients. On arriving disseminated tumour cells enter a mechanical microenvironment that is substantially different primary largely regulated by cells. Osteocytes, ubiquitous cell type, orchestrate healthy remodelling response physical exercise. However, effects loadin...

Growth factor-induced cell migration and proliferation are essential for epithelial wound repair. Cell migration during wound repair also depends upon expression of laminin-5, a ligand for α6ß4 integrin. We investigated the role of α6ß4 integrin in laminin-5-dependent keratinocyte migration by re-expressing normal or attachment-defective ß4 integrin in ß4 integrin null keratinocytes. We found t...

Malignant astrocytomas are highly invasive neoplasms infiltrating diffusely into regions of normal brain. Whereas the molecular and cellular mechanisms governing astrocytoma invasion remain poorly understood, evidence in other cell systems has implicated a role for the Rho-GTPases in cell motility and invasion. Here, we examine how the inhibition or activation of Rho-kinase (ROCK) affects astro...

migration of compounds from packaging materials is one of the most important aspects of food safety. epoxy resins have been in inner coatings of food cans since the 1960s. these resins can be produced from bisphenol-a diglycidyl ether (badge) that is also utilized as a starter. migration of potentially toxic compounds in epoxy resins used for commercial cans is a very important food safety issu...

Chronic myelogenous leukemia (CML) results from transformation of a primitive hematopoietic cell by the BCR/ABL gene. The specific BCR/ABL signaling mechanisms responsible for transformation of primitive human hematopoietic cells are not well defined. Previous studies have suggested that constitutively activated tyrosine kinase activity plays an important role for in abnormal proliferation of C...

Hepatocellular carcinomas (HCC) are highly malignant and aggressive tumors lack of effective therapeutic drugs. Piperlongumine (PL), a natural product isolated from longer pepper plants, is recently identified as a potent cytotoxic compound highly selective to cancer cells. Here, we reported that PL specifically suppressed HCC cell migration/invasion via endoplasmic reticulum (ER)-MAPKs-CHOP si...

The migration of packaging material constituents into food is a product of the interaction between the food and packaging material. This phenomenon is of importance because some migrating substances may be toxicologically carcinogenic and endanger the consumer safety. Polystyrenes are used in many food-contact applications for the packaging of aqueous-based, fatty and dry foods. The correlation...