Different PIN-FORMED proteins (PINs) contribute to intercellular and intracellular auxin transport, depending on their distinctive subcellular localizations. Arabidopsis thaliana PINs with a long hydrophilic loop (HL) (PIN1 to PIN4 and PIN7; long PINs) localize predominantly to the plasma membrane (PM), whereas short PINs (PIN5 and PIN8) localize predominantly to internal compartments. However,...

Protein interaction networks (PINs) are often used to “learn” new biological function from their topology. Since current PINs are noisy, their computational de-noising via link prediction (LP) could improve the learning accuracy. LP uses the existing PIN topology to predict missing and spurious links. Many of existing LP methods rely on shared immediate neighborhoods of the nodes to be linked. ...

Fraud victims are often refused a refund by their bank on the grounds that they failed to comply with their bank’s terms and conditions about PIN safety. We, therefore, conducted a survey of how many PINs people have, and how they manage them. We found that while only a third of PINs are ever changed, almost half of bank customers write at least one PIN down. We also found bank conditions that ...

Humeral neck fractures can be stabilized using a bundle of intramedullary pins as described by Hackethal. In order to decrease the risk of pin migration, packing of the medullary cavity with as many pins as possible is sometimes recommended, but others believe that stability can be decreased by destruction of cancellous bone in the humeral head by a large bundle of pins. A surgical neck fractur...

Multifilamentary Nb-Ti superconducting wires with heterogenous flux pinning nano-structures have been fabricated using artificial pinning center (APC) technology. Pinning centers were introduced into Nb-Ti filaments, consisting of Cu-Ni, Nb and Nb+Ti rods with the triangular arrangement and the volume fraction of 17 %. After final hot extrusions, the APC wires were drawn down over a high strain...

OBJECTIVE To analyze the rigidity of a platform-type external fixator assembly, according to different numbers of pins on each clamp. METHODS Computer simulation on a large-sized Cromus dynamic external fixator (Baumer SA) was performed using a finite element method, in accordance with the standard ASTM F1541. The models were generated with approximately 450,000 quadratic tetrahedral elements...

Spatial problems and a variety of abstract problems can be solved by humans with more ease if the problem can be visualized and/or manipulated. Elaborating on the differences and interplay between representing spatial problems and solving them, this paper focuses on exploring the qualities of a strings and pins problem solving domain. This domain is compared to the straightedge and compass doma...

During asymmetric cell division, alignment of the mitotic spindle with the cell polarity axis ensures that the cleavage furrow separates fate determinants into distinct daughter cells. The protein Inscuteable (Insc) is thought to link cell polarity and spindle positioning in diverse systems by binding the polarity protein Bazooka (Baz; aka Par-3) and the spindle orienting protein Partner of Ins...

The insula plays a key role in brain processing of noxious and innocuous thermal stimuli. The anterior and the posterior portions of the insular cortex are involved in different ways in nociceptive and thermoceptive processing. Therefore, their stimulus-specific functional connectivity may also differ. Here we used functional magnetic resonance imaging (fMRI) to investigate the activity and fun...