The genetic influence on the response of nonpregnant nulliparous mice to foster placenta was investigated. Two highly inbred strains (BALBI cBy and C57BL/6By), their F 1 hybrids, a backcross generation, and seven recombinant-inbred strains derived from the F2 generation were tested. It was concluded that there is a genetic component to the response of female. mice to placenta in the absence of ...

Mouse readiness for gene manipulation allowed the production of mutants with breathing defects reminiscent of breathing syndromes. As C57BL/6J and FVB/N inbred strains were often used as background strains for producing mutants, we compared their breathing pattern from birth onwards. At birth, in vivo and in vitro approaches revealed robust respiratory rhythm in FVB/N, but not C57BL/6J, neonate...

SWRIJ mice avoid sucrose octaacetate (SOA) solutions at concentrations which other inbred strains do not. This phenotypic difference has been hypothesized to result from variation at a single autosomal locus with two alleles, one dominant (Soa a, aversion) and one recessive (Soa b, blind). Data from reciprocal F1 and F2 crosses of SWR/J (taster) and C57BL/6J (nontaster) mice and from four gener...

Inbred CBA/H mice are susceptible to radiation-induced acute myeloid leukemia (r-AML), and C57BL/6 mice are resistant. A genome-wide screen for linkage between genotype and phenotype (r-AML) of 67 affected (CBA/H x C57BL/6)F1 x CBA/H backcross mice has revealed at least 2 suggestive loci that contribute to the overall lifetime risk for r-AML. Neither is necessary or sufficient for r-AML, but re...

1. On the 4th day of gestation, embryos were recovered from mice of the C57BL, RIII, JU, C3H and Q strains, and cell counts were carried out. Significant differences between strains were seen, both in the percentage of embryos which had reached the blastocyst stage, and in the mean number of cells per embryo. C57BL embryos had most cells, and C3H embryos fewest. 2. Examination of earlier stages...

The intraperitoneal administration of aromatic hydrocarbons such as 3-methylcholanthrene, @-naphthoflavone, or naphthacene induces several monooxygenase activities and the new formation of a spectrally distinct CO-binding cytochrome in genetically “responsive” inbred mouse strains, but these compounds, even when administered chronically at high doses, fail to induce these changes in genetically...

Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in plasma concentrations of high-density lipoprotein (HDL) cholesterol across inbred mouse strains in response to high dietary fat intake. Several strains, including C57BL/6J, have stable levels of plasma HDL independent ...

Rabbi t antisera raised against rabbit corneal (SIRC) cells infected with xenotropic murine leukemia virus (MuLV) 1 contain antibodies specific for antigens related to the major glycoproteins (gp70) o f the xenotropic M u L V envelope (1). These antigens appear to be normal constituents of the cell surface o f lymphoeytes of all inbred mice and have been termed XenCSA-xenotropic M u L V envelop...

A number of recombinant inbred mouse strains (currently 48) have been developed from the strains A/J and C57BL/6J. These strains are likely to become an excellent probe in the study of genetic mechanisms underlying host resistance to infections and tumors.

Dystrophic cardiac calcinosis (DCC) occurs among certain inbred strains of mice and involves necrosis and subsequent calcification as response of myocardial tissue to injury. Using a complete linkage map approach, we investigated the genetics of DCC in an F(2) intercross of resistant C57BL/6J and susceptible C3H/HeJ inbred strains and identified previously a major predisposing quantitative trai...