نتایج جستجو برای: in vitro chemosensitivity and resistance assay
تعداد نتایج: 21789361 فیلتر نتایج به سال:
5-Fluorouracil (5-FU), a cell cycle-specific antimetabolite, is one of the most commonly used chemotherapeutic agents for colorectal cancer (CRC). Yet, resistance to 5-FU-based chemotherapy is still an obstacle to the treatment of this malignancy. Mutation or loss of Smad4 in CRC is pivotal for chemoresistance. However, the mechanism by which Smad4 regulates the chemosensitivity of CRC remains ...
abstract ion selective electrodes (ises) are electrochemical sensors that respond selectivity to the activity of ionic species. an ion-selective electrode is an electrochemical device that uses a thin selective membrane or film as the recognition element, and is an electrochemical half-cell equivalent to other half-cells of the zeroth (inert metal in a redox electrolyte). in common methods o...
Background & aimsAlthough bortezomib as one of the first line medicines that has greatly improved overall survival patients with multiple myeloma (MM), undesired drug resistance is frequently observed. Docosahexaenoic acid (DHA) and eicosapentaenoic (EPA) have been shown to be able enhance efficacy chemotherapeutic drugs in many cancer types. The aim present study was further evaluate anticance...
Introduction Cutaneous leishmaniasis is the most important parasitic disease. As the number of resistant types to glucantime (drug of choice) is increasing, it is needed to investigate the effects of other drugs like herbal medicines on this disease. Several studies have shown the anti Leishmania effects of olive leaf on the Leishmania and also some organisms. The goal of this study was to e...
BACKGROUND AND AIM The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in a large variety of solid tumors,including gastric cancer. Enriched on the surface of many tumor cells,CD24 promotes tumor growth,invasion and metastasis and confers resistance to some chemotherapeutic drugs.In this study, we investigated the possible effect of CD24 suppression o...
BACKGROUND Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents. However, the importance of these effects and whether there are differences in vitro and in vivo is unclear. METHODOLOGY/PRINCIPAL FINDINGS To assess the relative contr...
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