A highly oxidized form of a chitosan/dextran-based hydrogel (CD-100) containing 80% oxidized dextran aldehyde (DA-100) was developed as a post-operative aid, and found to significantly prevent adhesion formation in endoscopic sinus surgery (ESS). However, the CD-100 hydrogel showed moderate in vitro cytotoxicity to mammalian cell lines, with the DA-100 found to be the cytotoxic component. In or...

A principal requirement for biomedical alloys in device implantation is in vivo corrosion resistance, and optimal compatibility at the implant interface. In the context of materials science, biocompatibility is the ability of a material to assist a specific biological application and elicit an appropriate response, simulated in vitro or translated in vivo. The in vivo response of a device is de...

Microspheres of a hydrophobic and a hydrophilic poly(ether-ester) copolymer were evaluated for their in-vitro and in-vivo biocompatibility and degradation. The microspheres prior to and after sterilization were tested for in-vitro cytotoxicity. The invivo biocompatibility of the poly(ethylene glycol) terephthalate and poly(butylene terephthalate) (PEGT/PBT) microspheres was evaluated subcutaneo...

Titanium (Ti) and Ti-based alloy are widely used in the biomedical field owing to their excellent mechanical compatibility and biocompatibility. However, the bioinert bioactivity and biotribological properties of titanium limit its clinical application in implants. In order to improve the biocompatibility of titanium, we modified its surface with TiOx/TiNx duplex composite films using a new met...

The literature is used to analyse the significance of the use of iodine-impregnated incision drape (Ioban(®) 2) for the prevention of postoperative wound infections (SSI). The drape has a microbiocidal effect in vitro. Consequently an antiseptic effect also occurs under the incision drape when it is applied to the skin; at the same time, bacterial wound contamination is reduced. Overall, based ...

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...