BACKGROUND AND OBJECTIVE Percutaneous coronary intervention, despite being effective for coronary revascularization, causes in-stent restenosis due to neointimal hyperplasia in a large number of patients. The renin-angiotensin system is involved in neointimal hyperplasia. This study sought to evaluate seven gene polymorphisms of key renin-angiotensin system components, including angiotensinogen...

BACKGROUND In-stent restenosis is notoriously difficult to treat by repeat catheter intervention because of its propensity for aggressive recurrent neointimal formation. This study sought to assess the effectiveness and safety of the sirolimus-eluting stent in the treatment of in-stent restenosis. METHODS AND RESULTS The study was designed as a prospective multicenter registry. We included 16...

OBJECTIVES This study was undertaken to validate the in vivo intravascular ultrasound (IVUS) measurement of in-stent neointimal hyperplasia (IH) volumes. BACKGROUND Because stents reduce restenosis compared to balloon angioplasty, stent use has increased significantly. As a result, in-stent restenosis is now an important clinical problem. Serial IVUS studies have shown that in-stent restenosi...

One of the remaining challenges in interventional cardiology is in-stent restenosis. In-stent restenosis is difficult to treat, often recurs, and may require repeated interventions including bypass surgery and is therefore often frustrating for both the patient and the physician. If in-stent restenosis is severe and the relation with the patient’s complaints or proven ischaemia is clear, there ...

Balloon-stented angioplasty is a common treatment for carotid arterial atherosclerosis. Clinical studies have shown that within 6 months of the initial procedure, 25% of all stented-angioplasty patients develop restenosis, a postoperative narrowing of the artery due to plaque accumulation onto the stent. While hemodynamics, and more specifically low oscillatory wall-shear stress have been ident...

Trapping of interventional devices used to treat in-stent restenosis is rarely reported in the literature. Among those is a trapped rota ablation wire causing longitudinal stent deformation, sometime requiring another stent deployment onto the collapse stent. A Rota ablator getting stuck into the stent is very rare, and a lethal complication. We report a case of 79-year-old gentleman who underw...

Endoscopic treatment of a bronchial restenosis previously treated by insertion of a partially covered self-expandable metallic stent (SEMS) can be difficult. Classically, after recanalization of the bronchus, the stent is removed and replaced by a more adapted one. We report on two cases of proximal bronchial restenosis treated by insertion of an additional stent inside the lumen of the previou...

Over the last three decades, percutaneous coronary intervention (PCI) technology has revolutionized the field of cardiology. PCI began in the form of balloon angioplasty, and was followed by coronary stenting. In-Stent restenosis is the main limitation of coronary stenting, and has been delayed to some extent by the development of drug eluting stents. Coronary angioplasty with stenting is curre...

Background: Recently, different investigators have studied the possibility of radiation therapy in restenosis prevention and have shown promising results. In this study a unique radioactive source for intra vascular brachytherapy (IVBT) was investigated. The two-dimensional dose distribution in water for a 32P IVBT stent has been calculated. The pure beta emitter source 32P has been co...

BACKGROUND We evaluated the clinical and angiographic outcomes of patients presenting with restenosis after sirolimus-eluting stent (SES) implantation treated with repeated percutaneous intervention. METHODS AND RESULTS A total of 24 consecutive patients have undergone repeated percutaneous intervention to treat post-SES restenosis (27 lesions). The restenosis was located within the stent in ...