Sustained drug delivery has become the standard in modern Pharmaceutical design and an intensive research has been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in-situ forming polymeric delivery systems such as ease of administration and reduced frequency of administration, improved patient comp...

Despite numerous scientific efforts many challenges need to be overcome in the ocular delivery because eyes have special and complex anatomic structures. The main problem with the conventional dosage forms is poor ocular bioavailability due to minimum ocular residence time, because of various anatomical and pathophysiological barriers prevailing in the eye. For this reason, much effort has been...

To increase the low bioavailability and short ocular residence time of ciprofloxacin eye drops, aqueous solutions of drug in chitosan/ Pluronic (poloxamer) were prepared to identify suitable compositions with regard to gel forming properties and drug release behavior. Mixtures of solutions of Pluronic (10-25% w/w) with chitosan (0.1-0.3% w/w) of different molecular weights (Mw) were prepared. C...

Environmentally responsive gel formulation for ocular controlled delivery of carteolol hydrochloride (HCl) was developed in an attempt to improve ocular bioavailability and hence decrease its systemic absorption and side effects. The viscosity and the ability of the prepared formulations to deliver carteolol HCl in vitro and in vivo were monitored and compared with an aqueous commercial solutio...

The aim of this study was to evaluate the efficacy of a hyaluronic acid containing eye drop in ameliorating ocular surface pathology and discomfort in canine keratoconjunctivitis sicca (KCS). Twenty five dogs with KCS treated with a topical carbomer (CA)-based tear replacement gel were moved to treatment with a hyaluronic acid (HA)-containing tear replacement eye drop. Dogs were subject to a fu...