globally, brucella melitensis and b. abortus are the most common cause of human brucellosis. the outer membrane protein 31 (omp31) and l7/l12 are immunodominant and protective antigens conserved in human brucella pathogens which are considered as potential vaccine candidates. we aimed to design the fusion protein from brucella l7/l12 and truncated omp31proteins, in silico , clone the fusion in ...

The adverse effects to humans and environment of only few chemicals are well known. Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco/toxicokinetics that determine the internal dose of chemicals to which the organism is exposed. Of all the xenobiotic-metabolizing enzymes, the cytochrome P450 (CYP) enzymes are the most important due to their abundance and versa...

Bioequivalence testing aims to ensure that the therapeutic performance of drug is consistent and reproducible when it administrated. Modeling simulation in silico methods are currently performed conduct virtual bioequivalence studies. Various computer software used generate model input data. This review summarizes for predicting vivo which supports analysis testing. GastroPlus™ SimCyp® widely p...

le besoin croissant de logement et le desir dameliorer la qualite, la securite et la durabilite des batiments, et de diminuer leur prix de revient, ont necessite des recherches etendues dans le domaine des materiaux de la construction. le beton silico-calcaire peut etre considere comme une des reussites remarquables de ces recherches. / le beton silico-calcaire est obtenu par l*acceleation de l...

We have adapted the originally described electronic PCR (e-PCR) algorithm to perform string searches more accurately and much more rapidly than previously possible. Our implementation [multithreaded e-PCR (me-PCR)] runs sufficiently fast to allow even desktop machines to query quickly large genomes with very large genomic element sets. In addition, me-PCR is multithreaded, interprets all IUPAC ...