نتایج جستجو برای: in andersens tales
تعداد نتایج: 16979131 فیلتر نتایج به سال:
Transcription factors (TFs) act withinwider regulatory networks to control cell identity and fate. Numerous TFs, including Scl (Tal1) and PU.1 (Spi1), are known regulators of developmental and adult haematopoiesis, but how they act within wider TF networks is still poorly understood. Transcription activator-like effectors (TALEs) are a novelclassofgenetic toolbasedon themodularDNA-bindingdomain...
Transcription activator-like effectors (TALEs) contain modular programmable DNA binding domains. Fusing TALEs with effector domains creates synthetic transcription factors (TALE-TFs) or nucleases (TALENs), enabling precise gene manipulations. The construction of TALEs remains challenging due to their repetitive sequences. Here we report a simple TALE assembly reaction (STAR) that enables indivi...
This paper critically analyzes Geoffrey Chaucer’s character Allison of his tale “The Wife of Bath” within the Canterbury Tales. The argument is made that Chaucer intentionally used this character to present his personal feminist ideals to his audience, thereby acting as an advocate for women under the guise of literary author. Evidence will be presented both from the text by analyzing her chara...
A little over twenty years ago, a group of scientists assembled in Asilomar, California, to consider the consequences of the newly invented techniques of genetic engineering, or recombinant DNA, as it later came to be called. There was in place a moratorium recommended by scientists and which we, working for the UK's Medical Research Council, had been instructed to heed by the Secretary of the ...
The ability to conditionally rewire pathways in human cells holds great therapeutic potential. Transcription activator-like effectors (TALEs) are a class of naturally occurring specific DNA binding proteins that can be used to introduce targeted genome modifications or control gene expression. Here we present TALE hybrids engineered to respond to endogenous signals and capable of controlling tr...
In Japan, most of children haven’t read children’s story (Fairy tales or tales of old Japan) because the high technology video games are more exciting than most of picture books. But they must be effective to bring up the children’s cultivation of aesthetic sensitivity. And we have heard from teachers of elementary schools that most of themes of computer education in school are the operation of...
Designer transcription-activator like effectors (TALEs) is a promising technology and made it possible to edit genomes with higher specificity. Such specific engineering and gene regulation technologies are also being developed using RNA-binding proteins like PUFs and PPRs. The main feature of TALEs, PUFs and PPRs is their repetitive DNA/RNA-binding domains which have single nucleotide binding ...
Xanthomonas TALE transcriptional activators act as virulence or avirulence factors by activating host disease susceptibility or resistance genes. Their specificity is determined by a tandem repeat domain. Some Xanthomonas pathogens contain 10-30 TALEs per strain. Although TALEs play critical roles in pathogenesis, their studies have so far been limited to a few examples, due to their highly rep...
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