HIV or human immunodeficiency virus infection has assumed worldwide proportions and importance in just a span of 25 years. Continuous research is being done in many parts of the world regarding its treatment and vaccine development, and a lot of money has flown into this. However, fully understanding the mechanisms of immune depletion has still not been possible. The focus has also been on impr...

Abstract Background Emerging evidence has shown that intra-tumor immune features are associated with response to checkpoint blockade (ICB) therapy. Accordingly, patient stratification is needed for identifying target patients and designing strategies improve the efficacy of ICB We aimed depict specific pancreatic cancer explore implication diversity in prognostic prediction individualized immun...

Monophosphoryl lipid A (MPL) and oligodeoxynucleotide CpG are toll-like receptor (TLR) 4 and 9 agonist, respectively. Here, we investigated the effects of MPL, CpG, and combination adjuvants on stimulating in vitro dendritic cells (DCs), in vivo innate and adaptive immune responses, and protective efficacy of influenza vaccination. Combination of MPL and CpG was found to exhibit distinct effect...

The control and prevention of infectious diseases through immunization is one of the greatest achievements of modern medicine since Edward Jenner pioneered smallpox vaccination. However, future challenges in improving the efficacy of existing vaccines, development of new prophylactic vaccines for infectious diseases and therapeutic immunization for noninfectious diseases require extensive work ...

Vaccine efficacy is optimized by addition of immune adjuvants. However, although adjuvants have been used for over a century, to date, only few adjuvants are approved for human use, mostly aimed at improving vaccine efficacy and antigen-specific protective antibody production. The mechanism of action of immune adjuvants is diverse, depending on their chemical and molecular nature, ranging from ...

conclusions the results of our study show that serum zinc level in bronchiectasis patients was lower than the control group and the difference was statistically significant. it seems that the use of zinc supplement can reduce progression of the infectious disease regarding its role in improving the immune system reactions and some unknown mechanisms. therefore, prophylactic and therapeutic use ...

multiple sclerosis is an autoimmune disease of the central nervous system which is accompanied by demyelinating the neurons. the imbalance between the t cell effectors and t cell regulators is thought to have a role in the pathogenesis of the disease. melatonin is a hormone that is secreted by pineal gland which has an important role in circadian rhythm and immune-modulatory effects. melatonin ...

this study evaluated the effects of probiotic, lactobacillus plantarum on serum biochemical and some immune parameters of immunized rainbow trout weighting 29.6±1.84 g, with streptococcosis/lactococosis vaccine at 16±1.5°c, for 60 days. a commercial diet was used as the control. fish in the first treatment were immunized with streptococcosis/lactococosis vaccine in bathing route for 1 min. in t...