Supplier-Customer relationships, considered as veritable sites of investment by the marketing firm, evolve over time to condition the position of the firm in its market, providing its strategic identity. This evolution is strongly influenced by less tangible elements intrinsically linked to exchanges taking place over time : the relationship " atmosphere " , often discussed in the literature re...

Cisplatin is a crucial agent in the treatment of many solid tumors, yet many tumors have either acquired or intrinsic resistance to the drug. We have used the homozygous diploid deletion pool of Saccharomyces cerevisiae, containing 4728 strains with individual deletion of all nonessential genes, to systematically identify genes that when deleted confer sensitivity to the anticancer agents cispl...

The insulin-like growth factor II (IGF2) mRNA binding protein (IMP) p62/IMP2-2, originally isolated from a hepatocellular carcinoma (HCC) patient, induces a steatotic phenotype when overexpressed in mouse livers. Still, p62 transgenic livers do not show liver cell damage but exhibit a pronounced induction of Igf2 and activation of the downstream survival kinase AKT. The aim of this study was to...

Compared with yeast, our knowledge on members of the ATP-independent plant mitochondrial proteolytic machinery is rather poor. In the present study, using confocal microscopy and immunoblotting, we proved that homologs of yeast Oma1, Atp23, Imp1, Imp2, and Oct1 proteases are localized in Arabidopsis mitochondria. We characterized these components of the ATP-independent proteolytic system as wel...

Intrapulmonary percussive ventilation (IPV) is a ventilatory technique that delivers bursts of high-flow respiratory gas into the lung at high rates, intended for treating acute respiratory failure and for mobilization of secretions. We performed a study, aimed at assessing the physiological response to IPV, on patients' breathing pattern, inspiratory effort, lung mechanics and tolerance to ven...

Non-alcoholic fatty liver disease (NAFLD) represents the most common hepatic manifestation of chronic liver diseases in developed countries. Since non-alcoholic steatohepatitis (NASH) is responsible for a large proportion of cryptogenic cirrhosis and cirrhosis represents the main risk factor for hepatocellular carcinoma (HCC), HCC is a severe complication of end-stage NAFLD. Recent evidence pub...

In this paper we review extant studies and report new empirical insights regarding connected relationships within a focal firm’s network horizon. Furthermore, we discuss possible reasons for how and why knowledge and ignorance of different types of connections are dispersed in industrial structures. The Industrial Network Approach and the concept of connected relationships “One critical specifi...

This report describes the languages defined to interface between various components which are developed within work-package 5. At a later point of time, these languages will also become visible to other components in other work-packages as well as to users of the authoring environment. Chapter 1 gives an introduction and relates the following chapters to each other. Ch. 2 describes the language...