mycophenolic acid is a secondary extracellular metabolite of penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. the aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by penicillium brevi-compactum atcc16024 was investigated. batch submerged fer...

results it was found that the positive hepatitis b surface antigen (hbsag), the high baseline hbv dna level, the positive hepatitis b virus e antigen (hbeag), and an absent or low hepatitis b surface antibody (hbsab) titer prior to starting treatment are the most important viral risk factors. furthermore, rituximab, anthracycline, and different types of tnf-α inhibitors were identified as the h...

BACKGROUND There is concern that the incidence of non-Hodgkin's lymphoma (NHL) will rise with increasing use of immunosuppressive therapy. AIMS Our aim was to determine the risk of NHL in a large cohort of patients with inflammatory bowel disease (IBD), and to study the association between IBD, NHL, and immunosuppressive therapy. METHODS We studied 782 IBD patients (238 of whom received imm...

The anterior chamber of the eye is an immunologically privileged site. Over the past 15 years, numerous laboratories documented that the privileged status of this unique site is mediated by multifactorial immunoregulatory processes. Among the participating factors is the aqueous humor that circulates in the anterior chamber and is in contact with most of the tissues in the anterior segment of t...

Because there have been reports that factor IX concentrate is less immunosuppressive and therefore factor IX users have less immunologic aberrations, we have studied a group of 22 patients with hemophilia B and six patients with factor VIII deficiency and high titer inhibitors with respect to lymphocyte numbers and function, human immunodeficiency virus (HIV) serology, and factor usage. This gr...

Introduction. The occurrence of the new-onset diabetes after kidney transplantation is common and represents a risk factor for decreased survival of the graft and the patient. Case presentations. We report 6 cases of diabetes appeared in post renal transplantation. Treatment after kidney transplantation was based on corticosteroids associated with immunosuppressive therapy in all cases. Diabete...