Saponins are common in a large number of plants and plant products. It is having important role in human and animal nutrition. Saponins have biological role as membrane-permeabilising, immunostimulant and hypocholesterolaemic properties and it has found to have significant affect growth and feed intake in animals. These compounds have been observed to kill protozoans, to impair the protein dige...

The effect of combining chemotherapy and immunostimulation, induced by a chemical, against a murine lymphoid leukemia was investigated. When tetramisole or levamisole were used following one administration of 1,3-bis(2-chloroethyl)-l-nitrosourea, a significantly higher percentage of long-term surviviors occurred in contrast to the groups of animals treated with drug or immunostimulant alone. Th...

Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synthesis and mitosis accompanied by a marked increase in expression of an array o...

Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and immunotherapy. Much research effort has focused on the mycobacterial glycolipid trehalose-6,6'-dimycolate (TDM), a potent immunostimulant that is also known as cord factor. Now, the identification of the monocyte-inducible C-type lectin (M...

Background Adoptive cell transfer (ACT) with autologous tumorreactive T cells is a promising strategy in cancer immunotherapy, but treatment of solid tumors is limited by the rapid decline in function of the transplanted T cells. In order to maintain high numbers of viable antigen-specific cytotoxic T cells in tumors, co-administration of supporting immunostimulant agents together with transfer...

Two extracts of different collections of the traditional medicine uña de gato (Uncaria tomentosa) from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages. The plant preparations greatly stimulated IL-1 and IL-6 production by rat macrophages in a dose dependent manner in the range of ...

The successful development of a mucosal vaccine depends critically on the use of a safe and effective immunostimulant and/or carrier system. This review describes the effectiveness and mode of action of an immunostimulating particle, derived from bacteria, used in mucosal subunit vaccines. The non-living particles, designated bacterium-like particles are based on the food-grade bacterium Lactoc...

Dewa mushroom is a saprophytic that can function as medicine, namely antihypertensive, antibacterial, anticancer, immunostimulant, anticholesterol, antiviral, and antioxidant. The content of secondary metabolites terpenoids, alkaloids, phenols have antibacterial activity. extract was obtained by stepwise extraction with hexane, dichloromethane, ethylacetate solvents. Testing activity diffusion ...

The improvement of fish immunity is a critical factor in successful aquaculture. In recent years, the use garlic (Allium sativum) as an immunostimulant has attracted researchers and farmers' interest enhancing fish's health disease resistance. This abstract discusses overview Garlic widely known for its antimicrobial, antioxidant, properties. Several studies have evaluated effects supplementati...

ABSTRACT Feed additives, such as β-glucans, nucleotides, ascorbic acid (vitamin C), and α-tocopherol E) can improve fish immunity contribute to enhanced zootechnical performance of the fish. This study aimed evaluate effect different concentrations vitamin- mineral premix with or without inclusion an immunostimulant boost (β-glucans, nucleotides vitamins C on performance, hemato-immunological p...