Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxal...

The number of platelets in the peripheral blood of healthy children, full-term, and premature infants falls into the same range as that of adults. Thrombocytopenia, defined as a platelet count of less than 150,000/mm(<150 × 10/L), may be due to decreased production, splenic sequestration, or increased platelet destruction. The following is a review of disorders involving the last mechanism, all...

Primary immune thrombocytopenia is an autoimmune disease mediated by antiplatelet autoantibodies that cause platelet destruction and suppression of platelet production. In vitro effects of autoantibodies on megakaryocyte production and maturation have been reported recently. However, the impact of these autoantibodies on crucial megakaryocyte functions, proplatelet formation and subsequent plat...

Sebaceous adenitis is an autoimmune disease that is seen mainly in the Standard Poodle, Akita, and English Springer Spaniel. The incidence of the disease in Standard Poodles appears to be low at this time but increasing in frequency over time. The disease is a generalized skin disorder associated with an attack by the dog’s own immune system against the sebaceous glands. The breed is known to s...

l)ocvtopenia both in animals and humans. 4 Evidence was subsequently presented, using the fluorescent antibody technique, that platelet antibody could often l)C found in the bone marrow, selectively attached to the surface of the megakaryocytes.5 ’ The hypothesis that in immune thrombocytopenia an antibody-mediated injury to the niegakaryocytes can, in part, be responsible for the low platelet ...

The immune chronic thrombocytopenic purpura is an illness characterized by peripheral thrombocytopenia occurred through a mechanism of early hyper destruction of blood platelets or by deficient platelet synthesis in the medulla. The chronic immune purpura can be primary, autoimmune in nature, thrombocytopenic idiopathic or secondary in the context of other associated pathologies. The idiopathic...

To test the role of T helper cell Th1 immunity we recruited 24 patients with idiopathic thrombocytopenia associated with H. pylori seropositivity. They were divided into 2 groups: 12 with immune-mediated thrombocytopenia (Group 1) and 12 with non-immune mediated thrombocytopenia (Group 2). We also recruited 10 individuals seronegative for H. pylori (Group 3) as controls. Initial platelet count ...