The use of glycosyltransferases in chemoenzymatic oligosaccharide synthesis is attractive, provided that the enzymes are available, since it eliminates the tedious multistep protectiondeprotection and chemical glycosylation procedure that characterizes classic chemical synthesis. The sugar nucleoside diphosphates (sugar-NDPs) that most glycosyltransferases require as glycosyl donors (e.g. UDP-G...

Lindgren, F. 2016. Si negative electrodes for Li-ion batteries. Aging mechanism studies by electrochemistry and photoelectron spectroscopy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1362. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9533-6. This thesis is focusing on the challenges when using Si as a possible new negat...

Triterpenoids are the most promising plant secondary metabolites. Several triterpenoids, including ursolic acid, oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol and avicins are representative group of phytochemicals possesses biological properties. Anti-tumor, anti-cancer, anti-biotic, cytotoxic, anti-inflammatory, anti-HIV, acetyl cholinesterase, anti-wrinkle and antifeedant act...

Oxidative stress-mediated destruction of normal parenchymal cells during hepatic inflammatory responses contributes to the pathogenesis of immune-mediated hepatitis and is implicated in the progression of acute inflammatory liver injury to chronic inflammatory liver disease. The transcription factor NF-E2-related factor 2 (Nrf2) regulates the expression of a battery of antioxidative enzymes and...

Matrix metalloproteinases (MMPs) degrade extracellular matrix components, and overexpression of these enzymes contributes to tissue destruction in arthritis. Of particular importance are the collagenases, MMP-1 and MMP-13, which have high activity against the interstitial collagens in cartilage. In this study, we address the mechanisms of two inhibitors of collagenase gene expression, the synth...

Eukaryotic mRNA with its 5′-cap is of central importance for the cell. Many studies involving mRNA require reliable preparation and modification of 5′-capped RNAs. Depending on the length of the desired capped RNA, chemical or enzymatic preparation – or a combination of both – can be advantageous. We review state-of-the art methods and give directions for choosing the appropriate approach. We a...