The octapeptide NAP has been shown to exert neuroprotective properties. Here, we investigated potential anti-inflammatory effects of NAP in an acute ileitis model. To address this, C57BL/6j mice were perorally infected with Toxoplasma gondii (day 0). Within 1 week postinfection (p.i.), placebo (PLC)-treated mice developed acute ileitis due to Th1-type immune responses. Mice that were subjected ...

INTRODUCTION In Crohn's disease, the extension of active terminal ileitis into a Meckel's diverticulum is possible, but usually has no impact on clinical decision-making. We describe an original surgical approach in a young woman presenting with a combination of perforated Meckel's diverticulitis and active Crohn's ileitis. CASE PRESENTATION We report the case of a 22-year-old woman with Croh...

DIET COMPOSITION AND ILEITIS IN PIGS 3 1 2 Effect of dietary inclusion of distiller’s dried grains with solubles, soybean hulls, 3 or a polyclonal antibody product on the ability of growing pigs to resist 4 a Lawsonia intracellularis challenge 5 6 M. H. Whitney, G. C. Shurson, and R. C. Guedes 7 8 Departments of Animal Science and Veterinary Biosciences, University of 9 Minnesota, St. Paul 5510...

A 76 year old woman presented with abdominal pain and weight loss. At laparotomy she was found to have an adenocarcinoma of the ileum arising in a segment of tuberculous ileitis. The possible significance of this association is discussed.

Abstract Background Crohn’s disease can involve any segment of the gastrointestinal tract, with terminal ileum being most common affected part. The wireless or video capsule endoscopy (VCE) is a valuable diagnostic tool in detecting lesions small bowel beyond ileum. findings procedure combination other clinical, endoscopic and laboratory factors determine therapeutic plan. Herein, we analyzed V...

BACKGROUND Oral infection of C57BL/6J mice with the protozoan parasite Toxoplasma gondii leads to a lethal inflammatory ileitis. PRINCIPAL FINDINGS Mice lacking the purinergic receptor P2X7R are acutely susceptible to toxoplasmic ileitis, losing significantly more weight than C57BL/6J mice and exhibiting much greater intestinal inflammatory pathology in response to infection with only 10 cyst...

The ability of the lymphatic system to actively remove fluid from the interstitium is critical to the resolution of edema. The response of the lymphatics to inflammatory situations is poorly studied, so we examined mesenteric lymphatic contractile activity in the 2,4,6-trinitrobenzenesulfonic acid (TNBS) model of guinea pig ileitis, a well-accepted animal model of intestinal inflammation, by vi...

In the chronically inflamed ileum, unique mechanisms of alteration of similar transport processes suggest regulation by different immune-inflammatory mediator pathways. In a rabbit model of chronic ileitis, we previously demonstrated that Na+-glucose cotransport was inhibited by a decrease in the cotransporter numbers, whereas Na+-amino acid cotransport was inhibited by a decrease in the affini...

Sundaram, U., S. Wisel, S. Stengelin, W. Kramer, and V. Rajendran. Mechanism of inhibition of Na1-bile acid cotransport during chronic ileal inflammation in rabbits. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38): G1259– G1265, 1998.—In the chronically inflamed ileum, unique mechanisms of alteration of similar transport processes suggest regulation by different immune-inflammatory mediat...