The synthesis of various substituted Biginelli 3,4-dihydropyrimidinone/thione and Hantzsch 1,4dihydropyridine derivatives has been achieved using a modified procedure in the presence of potassium ter-butoxide (tBuOK) as a catalyst under solvent-free conditions, in good to excellent yields.

A new imidazole-2-thione fused furazan biheterocyclic group was synthesized and its biological activity investigated. Nitrogen rich heterocycles, 1,2,5-oxadiazole (furazan) have been conveni ently fused. To accomplish this, we improved a strategy that silica gel supported solvent free micro wave dehydration of vicinal dioximes. The target "N,N’-diphenyl-4H-imidazo[4,5-c]furazan-5(6H) –thio ne" ...

A series of new clubbed aryl oxadiazole-1,2,4-triazine derivatives (6a-l) were designed and synthesized using appropriate chemical routes. The structures to have the required structural elements for any compounds be potential anticonvulsant. Preliminary screening anticonvulsant activity was performed maximal electroshock seizure (MES), subcutaneous pentylenetetrazole-induced (scPTZ) behavioral ...

a series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. the 4-amino-1,2,4-triazole-5-thione analogues (ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

The inhibition activity of thione–thiol tautomers of 2-mercapto-1-methylimidazole (MMI), namely 1-methyl-1Himidazole-2 (3H)-thione (M1) and 1-methyl-1H-imidazole-2-thiol (M2) has been performed using density functional theory (DFT) B3LYP/6-311G (d, P) basis set level in order to elucidate the different inhibition efficiencies of these compounds as corrosion inhibitors. The calculated structural...

Three diazoles namely 5-methyl-1,3,4-oxadiazole -2(3H)-thione, 5-methyl-1,3,4-thiadiazol-2(3H)-thione and 4-amino-5-methyl-2H-1,2,4-triazole-3-thiol were synthesized from acetic acid or ethyl acetate. Seco-acyclo-N-nucleoside analogous was by condensation of 1,3-benzylidine-glyceryl-2-tosylate with the three diazoles. Structural proof based upon IR, 1H-NMR, 13C-NMR spectroscopy MS measurements....

The molecular structures of two Pyridazine derivative;5-phenyl-6-ethyl-pyridazine-3-thione (PEPT) and 5-phenyl-6-ethylpridazine-3-one (PEPO) were simulated for corrosion inhibition efficiency using quantum chemical calculations based on density functional theory (DFT) at the B3LYP/6-31G* basis set level in order to compare relationship between their structure,electronic structure potential.The ...

Pressure-induced superconducting behavior was found in two anion radical salts, EtMe3Z[Pd(dmit)2]2 (dmit = 1,3-dithiole-2-thione-4,5-dithiolate, Z = P, As), that are Mott insulators and exhibit different magnetic and structural transitions at ambient pressure.

A phenylethynyl Fischer carbene complex was used as a traceless directing group for the regioselective cycloaddition of dithiolethiones to arylacetylene, which constitutes the first synthesis of E-dithiafulvene thione or dithioesters.