The paper presents a differential equation model for the feedback mechanisms between gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), development of follicles and corpus luteum, and the production of estradiol (E2), progesterone (P4), inhibin A (IhA), and inhibin B (IhB) during the female menstrual cycle. Compared to earlier human cycle models...

A loss of expression of fibroblast growth factor (FGF) receptor 2 IHb (FGFR2IIIb), which responds to stroma-derived FGF, accompanies pro gression of premalignant androgen-responsive rat prostate tumor epithe lial cells to the malignant phenotype. Concurrently, the level of FGFR2 gene expression is reduced and lost altogether in over 30% of cells, whereas all malignant cells abnormally express F...

A systematic study of the antioxidation mechanisms behind hydroxyl (•OH) and hydroperoxyl (•OOH) radical scavenging activity of piceatannol (PIC) and isorhapontigenin (ISO) was carried out using density functional theory (DFT) method. Two reaction mechanisms, abstraction (ABS) and radical adduct formation (RAF), were discussed. A total of 24 reaction pathways of scavenging •OH and •OOH with PIC...

The major thrust of scientific research is to understand and explain the biological functions of biological systems in molecular terms. The development of techniques of molecular modeling has opened the prospects for understanding the function, reactivity and properties of biological systems in terms of molecular structure. QSARs quantify the connection between the structure and properties of m...

A loss of expression of fibroblast growth factor (FGF) receptor 2 IHb (FGFR2IIIb), which responds to stroma-derived FGF, accompanies pro gression of premalignant androgen-responsive rat prostate tumor epithe lial cells to the malignant phenotype. Concurrently, the level of FGFR2 gene expression is reduced and lost altogether in over 30% of cells, whereas all malignant cells abnormally express F...

Dynamics, control, and stability of roll oscillations a biased ship in regular sea waves are investigated. The under oscillation is modelled as the classical Helmholtz–Duffing oscillator with strongly nonlinear asymmetric restoring moment characteristics. incremental harmonic balance method, amended pseudo-arc-length continuation approach, employed to obtain uncontrolled controlled frequency re...

This study presents our view of unconventional and conventional intramolecular hydrogen bonds (HBs) for some beta-diketones theoretically and experimentally. According to our results, the groups such as Phenyl and t-But in beta positions increase and CF3 group decrease IHB strength, respectively. For better understanding of the substitution effects, the compounds with similar and different subs...

We have examined the effect of the protein kinase C (PKC) inhibitor, Staurosporine, on tumor necrosis factor (TNF)-induced cytotoxic action and augmentation of human immunodeficiency virus (HIV) expression on the chronically HIV-infected T-cell line, MOLT-4/HIV (HTLV-IHB strain). Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF...