نتایج جستجو برای: igvh mutation
تعداد نتایج: 291497 فیلتر نتایج به سال:
Objectives: Chronic lymphocytic leukemia (CLL) is anincurable disease with a highly variable clinical course. IgVH mutationalstatus, chromosomal aberrations, CD38 expression and ZAP-70expression are prognostic markers in CLL, however, they are notexclusively confined to this disease. We recently identified a novel CLL-specific gene (CLL upregulated gene1, CLLU1) that is excl...
Åleskog, A. 2002. Application of In Vitro Chemosensitivity Testing for Evaluation of New Cytotoxic Drugs in Chronic Lymphocytic Leukaemia. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1209, 75 pp. Uppsala. ISBN 91-554-5474-7 Despite major advances in the understanding of the biology of chronic lymphocytic leukaemia (CLL), progress...
objective(s): it has been reported that the mutation of the pre-core (pc) and basal-core promoter (bcp) may play an important role in the development of hbv-related hepatocellular carcinoma (hcc). in this study the pc and bcp mutations were investigated in chronic hbv patients. materials and methods:in this study, 120 chronic hbv patients from golestan, northeast of iran who were not vaccinated...
Ig gene rearrangement by Ig complementarity determinig region 3 (CDR3) spectratyping . Total RNA was extracted using RNeasy Minikit (Quiagen) or Nucleo Spin-RNA/protein (Macherey-Nagel) columns and was retrotranscribed with Advantage RT for PCR kit (Clontech). cDNA was amplified with the following fast performance liquid chromatography (FPLC) purified primers (Invitrogen): mu1 forward (FW), CAG...
BACKGROUND Flow cytometry allows specific assessment of the expression of ZAP-70, a promising new prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL), but suffers from a lack of multicenter standardization. DESIGN AND METHODS An optimized method for direct detection of ZAP-70 in flow cytometry was tested in a multicenter fashion. Adapted for frozen cells, this method includes a n...
BACKGROUND Follicular lymphoma is characterized by the t(14;18) translocation resulting in constitutive expression of BCL-2 protein; however approximately 10-15% of follicular lymphomas do not express BCL-2 protein, and a small fraction of these cases does not exhibit translocation of the BCL-2 gene either. It is highly debated whether cases of follicular lymphoma without BCL-2 gene rearrangeme...
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