The novel cytokine IL-31 and its receptor have been shown to play a central role in bridging the immune system with neurons, epithelial surfaces connective tissues. Although increasing evidence has demonstrated their inflammation, involvement expansion of distinct leukocyte subsets is not fully understood. Detailed analyses Il31-transgenic (Eμ-Lck) mice indicated that next induction pruritus sk...

The status of suppressor T cells (Ts) was assessed in seven children with the hyper IgE syndrome (recurrent staphylococcal infections, eczematous skin rash, and elevated serum IgE) to determine whether a deficiency in Ts is associated with increased IgE synthesis. When circulating T cells and their subsets were enumerated with the aid of monoclonal antibodies that identify T cells (T3), helper/...

The development of food allergy requires an immunological reaction directed to a food antigen. This reaction may involve immunoglobulin E (IgE) or T lymphocytes (T cells) or some components of both IgE and T cells (mixed IgE/non-IgE reaction). Food allergy can manifest as cutaneous, respiratory, systemic (anaphylaxis) or gastrointestinal (GI) symptoms. The GI manifestations are listed in Table ...

The authors review the literature for cases fulfilling the criteria for the proposed idiopathic generalized epilepsy syndrome (IGE) of absence status epilepsy described by Genton et al. (2008). Difficulties arising in diagnosing such cases are remarked, and possible overlapping with other proposed IGE syndromes is discussed.

Deep sea water intake improves skin symptoms and mineral imbalance and decreases serum IgE levels mad IgE-inducing cytokines, IL-4, IL-13 and IL-18 in patients with atopic eczema/dermatitis syndrome (AEDS), while distilled water intake fails to do so.

Serum IgE concentrations were determined and IgE turnover studies were performed in control individuals as well as in patients with several disease states. Patients with common variable hypogammaglobulinemia, thymoma and hypogammaglobulinemia, ataxia telangiectasia, and selective IgA deficiency had significantly decreased mean serum IgE concentrations. In turnover studies, this was found to be ...