Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) known to participate in aortic remodeling, but whether IgE mediates unknown. In the present study, we found serum elevation arterial (PAH) patients, hypoxia-induced PH mice and monocrotaline-induced rats. Neutralizing with an anti-IgE antibody was effective prev...

immunoglobulin e is one of the five classes of immonoglobulins that plays an important role in allergic diseases. production of monoclonal antibodies by a single clonotype against different epitopes of immunoglobulin e has high priority in development of diagnostic kits. in this study, an attempt was made to produce monoclonal antibodies against human immunoglobulin e. balb/c mice were immunize...

Anaphylaxis caused by allergen sensitization and vaccination is a serious health concern. The severity of anaphylaxis associated with the presence immunoglobulin E (IgE) antibodies that bind to allergens high affinity. Here, we report development unique Interleukin-13 (IL-13)-producing follicular helper T (TFH) cell subset, designated TFH2 cells, which tightly production high-affinity IgE antib...

the presence of immune factors in inflamed dental pulps, suggests that immune responses could participate in disease process. with regard to the presence of significant number of mast cells in pulpitis cases, the purpose of this study was to determine the correlation between concentration and presence of ige in supernatant fluids of explants cultures of different states of dental pulps. for thi...

Emerging data suggest that measurement of serum IgE to peanut components can be clinically helpful and more accurate than IgE to whole peanut to predict peanut allergy. Not all studies have used prospective samples, multiple components and oral challenges. Currently, there are no data on this topic involving Italian children. 32 patients (23 males; median age 9 years) with reported history for ...

Background: Several studies reported the clinical features of IgE-mediated hypersensitivity after ingestion of melon. Melon allergy is a common IgE-mediated fruit allergy in Iran. This prompted us to investigate immunochemical and molecular properties of the major allergen in melon fruit, to compare the IgE-binding capacity of the natural protein with the recombinant allergen, and to determine ...

Background and Aims: Recent evidence suggests that T helper (Th) 17 cells are involved in the emergence of asthma. Th17 cells have a key role in inducing inflammation in asthmatic airways thus Interleukin (IL)-17A, the main cytokine of Th17, contributes to airways inflammation. Materials and Methods: We evaluated the level of IL-17A and total immunoglobulin E (IgE) in sera of 100 asthmatic p...

In order to determine the normal values of total IgE in children, 3270 sera were taken from 0-14 year old males and females in different parts of Tehran, the capital of Iran. The technique which was used to measure total IgE was ELISA method using monoclonal anti-IgE antibody. The results of this research indicated that the lower value for IgE was detected in children at birth (X=3.S3 IU/m...