نتایج جستجو برای: ifn regulatory factor 3 irf3

تعداد نتایج: 2648868  

Journal: :The Journal of Experimental Medicine 2004
Andrea K. Perry Edward K. Chow Julia B. Goodnough Wen-Chen Yeh Genhong Cheng

TANK-binding kinase-1 (TBK1) and the inducible IkappaB kinase (IKK-i) have been shown recently to activate interferon (IFN) regulatory factor-3 (IRF3), the primary transcription factor regulating induction of type I IFNs. Here, we have compared the role and specificity of TBK1 in the type I IFN response to lipopolysaccharide (LPS), polyI:C, and viral challenge by examining IRF3 nuclear transloc...

Journal: :Journal of immunology 2008
Rowan Higgs Joan Ní Gabhann Nadia Ben Larbi Eamon P Breen Katherine A Fitzgerald Caroline A Jefferies

Induction of type I IFNs is a fundamental cellular response to both viral and bacterial infection. The role of the transcription factor IRF3 is well established in driving this process. However, equally as important are cellular mechanisms for turning off type I IFN production to limit this response. In this respect, IRF3 has previously been shown to be targeted for ubiquitin-mediated degradati...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Hideo Negishi Kosuke Matsuki Nobuyasu Endo Hana Sarashina Shoji Miki Atsushi Matsuda Keiko Fukazawa Naoko Taguchi-Atarashi Hiroaki Ikushima Hideyuki Yanai Junko Nishio Kenya Honda Yoichiro Fujioka Yusuke Ohba Tetsuo Noda Shun'ichiro Taniguchi Eisuke Nishida Yongliang Zhang Hongbo Chi Richard A Flavell Tadatsugu Taniguchi

A major function of innate immune receptors is to recognize pathogen-associated molecular patterns and then evoke immune responses appropriate to the nature of the invading pathogen(s). Because innate immune cells express various types of these receptors, distinct combinations of signaling pathways are activated in response to a given pathogen. Although the conventional wisdom is that these sig...

2012
Meng Zhang Lijuan Wang Xueying Zhao Kai Zhao Hong Meng Wei Zhao Chengjiang Gao

TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I)-mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF receptor-associated factor (TRAF)-interacting protein (TRIP) promotes proteasomal degradation of TBK1...

Journal: :Journal of Immunology 2021

Abstract IFN-induced protein with tetratricopeptide repeats (IFITs), known as canonical IFN-stimulated genes (ISGs), play critical roles in regulating immune responses against pathogens and maintaining homeostasis. How the IFIT5 regulates innate is rarely reported remains enigmatic. In this study, we discover that human (hIFIT5) functions a negative regulator of type I IFN (IFN) pathway HEK293T...

Journal: :Journal of virology 2007
Nigel Bourne Frank Scholle Maria Carlan Silva Shannan L Rossi Nathan Dewsbury Barbara Judy Juliana B De Aguiar Megan A Leon D Mark Estes Rafik Fayzulin Peter W Mason

Infection of cells with flaviviruses in vitro is reduced by pretreatment with small amounts of type I interferon (IFN-alpha/beta). Similarly, pretreatment of animals with IFN and experiments using mice defective in IFN signaling have indicated a role for IFN in controlling flavivirus disease in vivo. These data, along with findings that flavivirus-infected cells block IFN signaling, suggest tha...

Journal: :Journal of virology 2015
Sanna M Mäkelä Pamela Österlund Veera Westenius Sinikka Latvala Michael S Diamond Michael Gale Ilkka Julkunen

UNLABELLED Influenza B virus causes annual epidemics and, along with influenza A virus, accounts for substantial disease and economic burden throughout the world. Influenza B virus infects only humans and some marine mammals and is not responsible for pandemics, possibly due to a very low frequency of reassortment and a lower evolutionary rate than that of influenza A virus. Influenza B virus h...

Journal: :Journal of immunology 2009
Kai Yang He-Xin Shi Xin-Yi Liu Yu-Fei Shan Bo Wei She Chen Chen Wang

Virus infection induces host antiviral responses including induction of type I IFNs. Transcription factor IFN regulatory factor 3 (IRF3) plays an essential role and is tightly regulated in this process. Herein we report that TRIM21 (tripartite motif-containing 21) is significantly induced and interacts with IRF3 upon RNA virus infection. Ectopic expression or knockdown of TRIM21 could respectiv...

Journal: :Journal of immunology 2010
Céline Molle Michel Goldman Stanislas Goriely

In myeloid dendritic cells, activation of the IL-27p28 gene is selectively induced by ligands of TLR4 or TLR3, both coupled to the Toll/IL-1R-related domain-containing adaptor-inducing IFN/IFN regulatory factor (IRF)3 pathway. In response to both ligands, autocrine type 1 IFN production was required for optimal IL-27p28 expression. Type I IFN signaling was necessary for sustained IRF1 activatio...

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