CONTEXT Pancreatic adenocarcinoma presenting as idiopathic thrombocytopenic purpura has not been previously reported in the literature. CASE REPORT A newly diagnosed patient with metastatic pancreatic adenocarcinoma developed thrombocytopenic purpura prior to initiation of chemotherapy. Generalized petechiae were present and peripheral smear revealed giant platelets. Drug induced and other th...

Abstract Background Immune thrombocytopenic purpura (ITP) is a common autoimmune bleeding condition in children that is characterized by a decrease in the platelet count. The aims of this study were to define epidemiologic features of patients with primary ITP who were admitted to Mofid Children's Hospital, Tehran, Iran, in a 5-year period. Methods We retrospectively studied the records of ...

Untreated human immunodeficiency virus (HIV) can be complicated by opportunistic infections, including disseminated histoplasmosis (DH). Although endemic to portions of the United States and usually benign, DH can rarely act as an opportunistic infection in immunocompromised patients presenting with uncommon complications such as acute kidney injury and idiopathic thrombocytopenic purpura. We r...

BACKGROUND Type G immunoglobulins against ADAMTS13 are the primary cause of acquired (idiopathic) thrombotic thrombocytopenic purpura. However, the domains of ADAMTS13 which the type G anti-ADAMT13 immunoglobulins target have not been investigated in a large cohort of patients with thrombotic thrombocytopenic purpura. DESIGN AND METHODS Sixty-seven patients with acquired idiopathic thrombotic...

This case report presents a highly unusual finding of ectopic splenic tissue in both the thoracic and abdominal cavities in a patient with recurrent idiopathic thrombocytopenic purpura (ITP).

PURPOSE OF REVIEW Thrombotic thrombocytopenic purpura, a clinical syndrome characterized by thrombocytopenia and microangiopathic haemolytic anaemia, was almost universally fatal until the introduction of plasma exchange therapy in the 1970s. Current outcomes have improved dramatically with the initiation of prompt plasma exchange, a treatment routinely used without any real understanding of wh...

It is well known that idiopathic thrombocytopenic purpura occurs most commonly during childhood but its incidence is difficult to estimate. MacFarlane (1960) found that in 737 cases 45 per cent were aged 15 years and younger, while Wintrobe (1956) noted that in childhood purpura was most frequent between the ages of two and eight years. The disease is uncommon in the general population. The pre...