The ADP-ribosyltransferase 3 gene (ART3) has been reported to be associated with non-obstructive azoospermia (NOA) in the Japanese population. In this study, we aim to explore the possible association between the four single nucleotide polymorphisms (SNPs) (rs11097230, rs17001385, rs14773 and rs6836703) in ART3 gene and male infertility with spermatogenesis impairment in the Chinese population....

Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while the null g...

The review published by Kläver and Gromoll is a timely reminder of the everchanging landscape of the clinical andrology laboratory as well as the limitations of current approaches to properly diagnose and treat male infertility.1 In a variety of disciplines, the clinical relevance of epigenetic status is becoming increasingly apparent. In this paper, the authors review the various studies that ...

background: cytomegalovirus (cmv) is a prevalent infection in humans. recent studies have shown the role of cmv infection in male infertility disorder. aim: here we aimed to study the role of cmv infection in men with idiopathic infertility. materials and methods: we performed a case-control study of cmv serology in 200 patients attending male infertility clinic of a university hospital. there ...

sting by E Abstract Introduction: Intrauterine insemination (IUI) is a valid treatment for infertility with a cumulative pregnancy rate of 40–90% after 3–10 treatment cycles. Design: We prospectively studied the efficacy of a new simplified method for motile sperm preparation for IUI for both male causes of infertility, and for those diagnosed with idiopathic infertility. Methods: A prospective...

Polymorphisms of estrogen receptor (ER) genes have been implicated in male infertility, but studies of this association have produced conflicting results. The present study was conducted to examine whether polymorphisms within the ERα and ERβ genes are susceptibility factors for human male idiopathic infertility in Chinese men. We investigated the association between the ERα gene gene and PvuII...

Background Infertility is the inability of a couple to conceive after one and a half years of unprotected sex. Male infertility, which accounts for almost half of infertility cases, is considered as a major problem all over the world. The aim of this study was to investigate the association of CYP1A1 polymorphisms with idiopathic non-obstructive azoospermia in a South Indian cohort. MATERIALS...

No significant effective therapy has been established for patients with idiopathic male infertility up to now. In order to assess the role of androgens in idiopathic male infertility, testosterone (T) and 5 alpha-dihydrotestosterone (DHT) levels in isolated seminiferous tubules (intratubular levels) were measured by radioimmunoassay (RIA) in 100 patients with idiopathic male infertility. RIA of...