OBJECTIVE In order to improve the dissemination of new expert-based treatments for adolescents with anorexia nervosa, we have developed an innovative 1-week intensive family-based evaluation and treatment programme. Ages of the adolescents in the programme ranged from 10 to 18 years (mean = 15.0, SD = 2.1). We report the outcomes of the first 19 cases. METHOD Data were obtained from a retrosp...

Endogenous opiates have been implicated as regulators of mood and pain. Recent literature suggests a relationship between these internal opiates and ingestive behaviors in both animals and humans. The present study investigates this relationship by comparing the pain sensitivities of obese and nonobese subjects. Twenty-six subjects (18 females, 8 males) whose weight was 130% or greater of their...

We retrospectively identified 67 patients with severe or morbid obesity (body mass index ≥35 kg/m(2)) who had received intravenous vancomycin at our institution. We observed that an initial dose of 45 to 65 mg/kg vancomycin per day based upon ideal body weight rather than actual body weight was more predictive of initial trough concentrations between 15 and 20 mcg/mL.

OBJECTIVES The primary objective of this analysis was to characterise the steady-state pharmacokinetics (PK) of ethinylestradiol (EE) and drospirenone (DRSP) in a randomised Phase III study that investigated the contraceptive efficacy and safety of three different regimens of EE 20 µg/DRSP 3 mg. METHODS Non-linear mixed-effects modelling was used to develop population PK models ...

35. Farrell J, Petrovics G, McLeod DG, Srivastava S. Genetic andmolecular differences in prostate carcinogenesis between African American and Caucasian Americanmen. Int J Mol Sci. 2013;14(8): 15510-15531. 36. Fowke JH, Signorello LB, Chang SS, et al. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels amongAfrican-American and Caucasianmen. Cancer....

Objective: We tested the hypothesis that inadequate self-perception of body weight with or without obesity would be associated with common mental disorders (CMD). Method: We analyzed cross-sectional data from 4,030 university employees participating in the longitudinal Pró-Saúde Study Phase 1 (1999) in Rio de Janeiro. Participants (22-59 years of age) were invited to fill out a questionnaire th...

Objective: We tested the hypothesis that inadequate self-perception of body weight with or without obesity would be associated with common mental disorders (CMD). Method: We analyzed cross-sectional data from 4,030 university employees participating in the longitudinal Pró-Saúde Study Phase 1 (1999) in Rio de Janeiro. Participants (22-59 years of age) were invited to fill out a questionnaire th...

To date, the dosing of sugammadex is based on real body weight without taking fat content into account. We compared the reversal of profound rocuronium-induced neuromuscular blockade in morbidly obese patients using doses of sugammadex based on four different weight corrections. One hundred morbidly obese patients, scheduled for laparoscopic bariatric surgery under propofol-sufentanil anaesthes...