نتایج جستجو برای: ibandronate

تعداد نتایج: 387  

Journal: :The Clinical journal of pain 2008
Brenda Breuer Marco Pappagallo Fukiat Ongseng Chieh-I Chen Richard Goldfarb

OBJECTIVE Complex regional pain syndrome (CRPS) type I, also known as reflex sympathetic dystrophy, usually develops after trauma or immobilization, is characterized by focal pain and autonomic dysregulation, and sometimes focal trophic changes such as osteoporosis. The pathophysiology is unknown and there have been few controlled treatment trials. The purpose of this study was to obtain pilot ...

Journal: :Journal of managed care pharmacy : JMCP 2011
Karen E Martin Jingbo Yu H Eloise Campbell Jacob Abarca T Jeffrey White

BACKGROUND Despite widespread availability and use of oral bisphosphonates, fracture rates and associated medical costs are still high. Differences in fracture risk among these agents, if any, have not been quantified due to the lack of high-quality, head-to-head, randomized, controlled trials assessing this outcome. Randomized, placebo-controlled trials have shown that alendronate and risedron...

2012
Ingmar Ipach Torsten Kluba Petra Wolf Bertram Pontz Falk Mittag

Osteogenesis imperfecta (OI) is characterized by different signs including increased bone fragility, short stature, blue sclera, abnormal tooth growth and often secondary immobility. No curative therapy has been found for this rare disease up to now, and different pharmacological substances have been tried as treatment for severe forms of OI. Promising results were seen with intravenous bisphos...

Journal: :Anticancer research 2006
Maria Kiagia Eleni Karapanagiotou Adriani Charpidou Kalliopi Dilana Georgios Dionellis Ioannis Dannos Evangellos Georgiou Konstantinos N Syrigos

BACKGROUND The high prevalence of bone metastases in stage IV non-small cell lung cancer (NSCLC) patients contributes substantially to the burden of the disease by resulting in significant skeletal morbidity. Ibandronate is a new generation of bisphosphonates (BPs) with demonstrated clinical benefit in breast and prostate cancer patients with bone metastases. PATIENTS AND METHODS In 32 patien...

Journal: :Clinical Interventions in Aging 2008
Oliver Bock Dieter Felsenberg

Nitrogen-containing bisphosphonates are potent inhibitors of osteoclastic bone resorption. With their individually proven efficacy to significantly reduce the incidence of vertebral and/or non-vertebral fractures and with their overall beneficial safety profile, alendronate, ibandronate, risedronate, and zoledronate are considered today a treatment of first choice in postmenopausal osteoporosis...

Journal: :Clinical and experimental rheumatology 2015
Huifeng Yun Elizabeth Delzell Kenneth G Saag Meredith L Kilgore Michael A Morrisey Paul Muntner Robert Matthews Lingli Guo Nicole Wright Wilson Smith Cathleen Colón-Emeric Christopher M O'Connor Kenneth W Lyles Jeffrey R Curtis

OBJECTIVES Few studies have assessed the effectiveness of different drugs for osteoporosis (OP). We aimed to determine if fracture and mortality rates vary among patients initiating different OP medications. METHODS We used the Medicare 5% sample to identify new users of intravenous (IV) zoledronic acid (n=1.674), oral bisphosphonates (n=32.626), IV ibandronate (n=492), calcitonin (n=2.606), ...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011
Gunter von Minckwitz Sibylle Loibl Christian Jackisch Stefan Paepke Caroline Nestle-Kraemling Michael P Lux Nico Maass Rita Schmutzler Andreas du Bois Diethelm Wallwiener Sabine Vescia Kai Budischewski Manfred Kaufmann

BACKGROUND Genetic testing for inherited mutations in breast cancer genes provides valuable information for disease prevention. Today, premenopausal women with increased risk for breast cancer have only limited nonsurgical options to reduce their risk. METHODS The GISS trial, a randomized, multicenter, open-label phase II trial, assessed the feasibility of a preventive treatment with gosereli...

2017
Jialiang Guo Qi Zhang Jia Li Yansong Liu Zhiyong Hou Wei Chen Lin Jin Ye Tian Linlin Ju Bo Liu Tianhua Dong Fei Zhang Yingze Zhang

Non-union is a major clinical problem in the healing of fractures, especially in patients with osteoporosis. The systemic administration of drugs is time consuming and large doses are demanding and act slowly, whereas local release acts rapidly, increases the quality and quantity of the bone tissue. We hypothesize that local delivery demonstrates better therapeutic effects on an osteoporotic fr...

2014
Andrea Messori Valeria Fadda Dario Maratea Sabrina Trippoli Claudio Marinai

8 Abstract 9 Background In the present study, we undertook an 10 equivalence analysis on the effectiveness of the main anti11 reabsorptive agents indicated for women with osteoporosis. 12 Methods Our methodology was a combination of meta13 analysis (both pair-wise meta-analysis and network meta14 analysis) and equivalence testing. The end-point was the 15 incidence on new vertebral fractures. T...

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