BACKGROUND The in vivo mechanism by which inhibition of NO synthase impairs ischemia-induced coronary vascular growth is unknown. We hypothesized that production of the growth inhibitor angiostatin increases during decreased NO production, blunting angiogenesis and collateral growth. METHODS AND RESULTS Measurements were made in myocardial tissue or interstitial fluid (MIF) from dogs undergoi...

Rats receiving intragastric infusions of 2.5, 5.0, 7.5, or 10.0 ml of normal saline while their pylori are reversibly occluded suppress meal size to the smallest infusion and display a dose-dependent reduction across volumes [Phillips, R. J., and T. L. Powley. Am. J. Physiol. 271 ( Regulatory Integrative Comp. Physiol.40): R766-R779, 1996]. To evaluate the contributions of the vagus to this det...

We hypothesized that neutralization of TNF-alpha at the time of reperfusion exerts a salubrious role on endothelial function and reduces the production of reactive oxygen species. We employed a mouse model of myocardial ischemia-reperfusion (I/R, 30 min/90 min) and administered TNF-alpha neutralizing antibodies at the time of reperfusion. I/R elevated TNF-alpha expression (mRNA and protein), wh...

The reduction in Ca2+ concentration during diastole and relaxation occurs differently in normal hearts and in hypertrophied hearts secondary to pressure overload. We have studied some possible molecular mechanisms underlying these differences by examining the function of the sarcoplasmic reticulum and the expression of the gene encoding its Ca2(+)-ATPase in rat hearts with mild and severe compe...

Maher A El-Hashash1, Dalal B Guirguis1*, Nayera AM Abd El-Wahed2 and Mohamed A Kadhim3 1Chemistry Department, Faculty of Science, Ain Shams University, Abassia 11566, Cairo, Egypt 2Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical Industries, National Research Center, El Behos street, Dokki, Egypt 3Chemistry Department, Faculty of Science, Anbar University, Iraq

MIAN ZHANG, CHENG WANG, REBECCA CHENG, AMIRHASSAN SHAMS-ANSARI, AND MARKO LONČAR* John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA Department of Physics, Brown University, Providence, Rhode Island 02912, USA Department of Electrical Engineering and Computer Science, Howard University, Washington, DC 20059, USA *Corresponding aut...

The rapid atrial rate during atrial fibrillation (AF) decreases the ionic current density of transient outward K+ current, L-type Ca2+ current, and Na+ current, thereby altering cardiac electrophysiology and promoting arrhythmia maintenance. To assess possible underlying changes in cardiac gene expression, we applied competitive reverse transcriptase-polymerase chain reaction to quantify mRNA c...

The effects of acute bilateral ureteral obstruction (BUO) of 18-h duration on deep nephron and collecting duct function were studied by micropuncture in 11 weanling rats. After release of BUO glomerular filtration rate was reduced (178+/-15 vs. 1,343+/-119 mul/min per g kidney weight in shams), while urine flow was increased averaging 17.5+/-1.3 vs. 6.8+/-0.72 mul/min per g kidney weight in con...

In supersymmetry the anomalous magnetic moment of particles belonging to the same supermultiplet is related by simple sum rules. We study the modification of these sum rules in the case of the spontaneously broken N=1 global supersymmetry. MIRAMARE – TRIESTE September 1994 Permanent address: Department of Mathematics, Faculty of Science, Ain Shams University, Cairo, Egypt.