Two hundred and twelve lepromatous patients, presenting with suspected dapsone-resistant leprosy in the 5-year period 1 973-77, were taken into trial treatment with dapsone. Clinically, 55% have been proven to be dapsone resistant and the remainder are continuing to respond to full dosage dapsone after 4·5 to 9 years. This clinical observation contrasts with results of the dapsone-sensitivity s...

OBJECTIVE To assess the profile and describe the clinical presentations, clinico-histopathological profile, complications and treatment compliance of childhood leprosy at a tertiary care hospital in north-east district of Delhi during 2000-2009. DESIGN A retrospective institutional study of children less than 14 years of age diagnosed with leprosy and registered in a leprosy clinic during 200...

A male patient with lepromatous leprosy developed nasal regurgitation of food due to palatal palsy during Type 2 reaction. Early high-dose administration of corticosteroid achieved a prompt therapeutic response and he completely recovered from palatal palsy. The associated lagophthalmos, foot drop and ulnar paralysis persisted.

Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae , clinically present either as tuberculoid, borderline or lepromatous type. Erythema nodosum leprosum (ENL) is an acute humoral response in the chronic course of lepromatous leprosy. Although very severe ENL reactions are known in systemic leprosy, such severity is rare in ocular tissues. A leprosy uveitis patient suffere...

AIM To describe ocular manifestations in newly diagnosed borderline lepromatous (BL) and lepromatous leprosy (LL) patients in India. METHODS Ocular complications, at enrolment, occurring in all new borderline lepromatous and lepromatous leprosy patients detected by active case finding within the geographically defined leprosy endemic area of the Gudiyattam Taluk in India from 1991 to 1997 who...

BACKGROUND Lepromatous leprosy caused by Mycobacterium leprae is associated with antigen specific T cell unresponsiveness/anergy whose underlying mechanisms are not fully defined. We investigated the role of CD25(+)FOXP3(+) regulatory T cells in both skin lesions and M.leprae stimulated PBMC cultures of 28 each of freshly diagnosed patients with borderline tuberculoid (BT) and lepromatous lepro...

Discussion Tuberculoid Hansen’s is a disease occurring in an immunocompetent individual with granulomatous reaction in the tissue. Usually no bacillus is identifiable. Nerve involvement is common with thickening of the nerve and numbness of the corresponding region. Leprosy caused by Mycobacterium leprae is one of the oldest diseases on earth. It has its earliest description in India and China ...

Leprosy is a chronic infection caused by Mycobacterium leprae that affects the peripheral nerves, skin, and potentially other organs [1–5]. Although the worldwide prevalence of leprosy has decreased in the era of multi-drug therapy (MDT), the global detection of new cases of leprosy remains a concern, with more than 250,000 new cases of leprosy reported in 2007 [3]. The precise mechanism of tra...

A Workshop on Leprosy Chemotherapy was convened under the auspices of the U.S. Leprosy Panel of the U.S.-Japan Cooperative Medical Science Program of the National Institute of Allergy and Infectious Disease on 26 October 1975 in Bethesda, Maryland. The workshop provided a unique opportunity to bring together participants from other countries as well to discuss three of the most pressing issues ...