A 76-year-old woman with cervical cancer was treated nedaplatin, a platinum-based drug. After the initiation of treatment, she became aware numbness, dizziness, and loss appetite. Exploration causes revealed no clues, but blood tests hypocalcemia hypomagnesemia. She intravenous calcium magnesium, which resolved calcium, magnesium levels, her symptoms. diagnosed hypomagnesemia because nedaplatin...

Background and Purpose—ECG abnormalities and hypomagnesemia frequently occur after aneurysmal subarachnoid hemorrhage (SAH). Because hypomagnesemia is associated with several ECG abnormalities, we studied whether hypomagnesemia mediates ECG abnormalities after SAH. Methods—We prospectively studied a consecutive series of 62 patients admitted within 72 hours after aneurysmal SAH. A standard 12-l...

OBJECTIVE: To determine the frequency of hypomagnesemia in patients with ventricular tachycardia. Materials and Methods: It is a descriptive Cross-Sectional study conducted Department Cardiology, MTI-HMC, Peshawar from 20 Sept 2020 to Mar 2021 after approval Institutional Ethical Committee. Patients were managed according guidelines hospital protocol. After stabilization, data was collected. Ag...

BACKGROUND Familial hypomagnesemia with hypercalciuria and nephrocalcinosis is a rare autosomal recessive renal disease characterized by tubular disorders at the thick ascending limb of Henle's loop. It is caused by mutations in the tight junction structural proteins claudin-16 or claudin-19, which are encoded by the CLDN16 and CLDN19 genes, respectively. Patients exhibit excessive wasting of c...

Hypomagnesemia is the most common electrolyte disturbance seen upon admission to the intensive care unit (ICU). Reliable predictors of its occurrence are not described. The objective of this prospective study was to determine factors predictive of hypomagnesemia upon admission to the ICU. In a single tertiary cancer center, 226 patients with different diagnoses upon entering were studied. Hypom...

The past decade has witnessed multiple advances in our understanding of magnesium (Mg(2+)) homeostasis. The discovery that mutations in claudin-16/paracellin-1 or claudin-19 are responsible for familial hypomagnesemia with hypercalciuria and nephrocalcinosis provided insight into the molecular mechanisms governing paracellular transport of Mg(2+). Our understanding of the transcellular movement...

BACKGROUND Neonates and infants with hypomagnesemia present with seizures and psychomotor delay. OBJECTIVES The present study evaluated the changes in magnesium (Mg) levels and factors associated with these in the first three days of life. MATERIALS AND METHODS We monitored 50 clinically asymptomatic neonates; they were not given any magnesium supplements even if they had hypomagnesemia at ...