The Journal of Lancaster General Hospital • Winter 2006 • Vol. 1 – No. 3 ABSTRACT Chronic kidney disease (CKD) is a complex syndrome with a variety of comorbidities; in patients on hemodialysis, the most common are cardiovascular disease (CVD) and metabolic bone disease (renal osteodystrophy).1 The pathogenesis of renal osteodystrophy involves abnormal vitamin D levels and secondary hyperparath...

DOOR syndrome is a rare multisystem genetic disorder, consisting of deafness (sensorineural), onychodystrophy, osteodystrophy, and mental retardation. Seizures reported frequently in this condition are often refractory to treatment.

The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...

The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...

number, and an increase in the number of osteoclastic Introduction resorption bays demonstrating the increased rates of bone resorption in osteitis fibrosa. Renal osteodystrophy is the term used to describe the In addition, osteitis fibrosa is characterized by a skeletal complications of end-stage renal disease. It is prominent accumulation of fibroblastic cells around a multifactorial disorder...

A patient with chronic renal failure, a dialysis encephalopathy syndrome and renal osteodystrophy associated with aluminium intoxication developed an avascular necrosis of the left femoral head. Histological examination of the excised head confirmed the zone of avascular necrosis and demonstrated an exuberant formation of cartilage around this zone. Calcification was sparse and the cartilage ex...

Kidney is one of the most important organs in the regulation of mineral metabolism (Fukagawa et al., 2006). Chronic kidney disease (CKD) is a worldwide public health problem that affects 5% to 10% of the world population, with increasing prevalence and adverse outcomes, including progressive loss of kidney function, cardiovascular disease, and premature death (Eknoyan et al., 2004). Calcium and...