Administration of pertussis vaccine, consisting of whole, killed Bordetella pertussis organisms, causes hyperinsulinemia and enhanced secretion of insulin in response to a variety of secretagogues in rats and mice. In examining the time course and properties of this phenomenon, we discovered two distinct and separate effects of the bacteria on glucose and insulin levels in mice. First, a heat-s...

BACKGROUND Valproic acid (VPA), a widely used antiepileptic drug, has broad-spectrum activity against both generalized and partial epilepsy. Among the side effects of VPA, weight gain is frequently reported, although the real incidence and magnitude of this problem is unknown. Its pathogenesis is most likely multifactorial, and is controversial. METHODS In order to evaluate the role of hyperi...

OBJECTIVE To report prevalence rates of acanthosis nigricans (AN) and hyperinsulinemia and the association of AN with hyperinsulinemia compared with other known or suspected risk factors for type 2 diabetes in young American Indians. RESEARCH DESIGN AND METHODS A random sample of Cherokee Nation members aged 5-40 years was invited to participate in the Cherokee Diabetes Study, a cross-section...

Type 2 Diabetes Mellitus (Type DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. DM has close association IGF-1, where the active form of IGF-1 becomes elevated by reason fact hyperinsulinemia inhibits production IGF-binding proteins (IGFBP) 1/IGFBP 2. The ability to promote cell proliferation inhibit apoptosis, hence one risk...

Objective : to discuss the features of use drug liraglutide for treatment patients with obesity, analyze metabolic parameters dynamic and difficulties that arise during therapy, based on our own clinical observations. Materials methods article provides an analysis observations aged 54 47 years who received therapy exgenous constitutional obesity II degree. According examination results, both sh...

Differences in body fat distribution between diabetics and nondiabetics have been recognized for several decades; diabetics have a more centralized or upper body fat pattern than nondiabetics. Recently, attention has focused on fat patterning and also on hyperinsulinemia as possible risk factors for cardiovascular disease, as well. The case for insulin as a cardiovascular risk factor is bolster...

Hyperinsulinemia. is associated with an overexpression of mRNA for the ob protein leptin in rodent models of genetic obesity, and insulin has been reported to directly stimulate leptin mRNA in rat adipocytes. Human obesity is also associated with increased leptin mRNA as well as plasma levels, but there have been no reports of the effect of insulin on leptin secretion. We, therefore, tested the...

The last several years have witnessed tremendous interest in the hypothesis that insulin resistance and hyperinsulinemia contribute to the pathogenesis of hypertension. This hypothesis was stimulated by epidemiological studies that demonstrated an association between obesity, insulin resistance, and hypertension.Subsequent studies suggested that even lean individuals with essential hypertension...

The relation between insulin resistance/ hyperinsulinemia and cardiovascular disease may be related to one of the cardiovascular effects of insulin. In acute experiments in humans, systemic euglycemic hyperinsulinemia induced vasodilation in skeletal muscle. Furthermore, the sympathetic nervous system is activated, although this does not lead to increase in blood pressure (BP). We hypothesized ...