نتایج جستجو برای: hyperactivation
تعداد نتایج: 2165 فیلتر نتایج به سال:
OBJECTIVE Cognitive impairments in Parkinson disease (PD) are thought to be caused in part by dopamine dysregulation. However, even when nigrostriatal dopamine neuron loss is severe enough to cause motor symptoms, many patients remain cognitively unimpaired. It is unclear what brain mechanisms allow these patients to remain cognitively unimpaired despite substantial dopamine dysregulation. ME...
T he spermatozoon is a marvelous machine designed by nature for the single task of finding an oocyte, delivering its genetic payload, and initiating the formation of a new embryo. Like many of the most specialized and sophisticated mechanical creations of humans, the sperm is fitted with unique components and stripped of unneeded hardware, including most of its biosynthetic equipment. As a cons...
Non-small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin. Cells manifesting elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) respond...
This paper discusses the clinical and pathogenetic aspects of hypertension comorbid with type 2 diabetes mellitus. The role sympathetic hyperactivation in mechanisms this comorbidity damage to target organ are reviewed. Authors analyze capabilities endovascular renal artery denervation discuss therapeutic effect procedure. article is intended for cardiologists, therapists, endocrinologists, sur...
The oviduct plays a vital role in ensuring successful fertilization and normal early embryonic development. The male inseminates many thousands or even millions of sperm, but this alone does not ensure that fertilization will be successful. The female tract, particularly the oviduct, provides filters that select for normal vigorously motile sperm. In conjunction with molecules in the seminal pl...
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