T he autistic spectrum comprises four subgroups: Asperger’s syndrome (AS), 2 and high, medium, and low functioning autism. They all share the phenotype of social difficulties and obsessional interests. In AS, the individual has normal or above average IQ and no language delay. In the three autism subgroups there is invariably some degree of language delay, and the level of functioning is indexe...

A fundameatal requirement of any parametrization of sub-gridscale orography (SSO) is that the total (resolved plus pa,rametrized) drag on a mountain rarge should be independent of the model horizontal resolution. However, parametrizations are typically developed and tested (ar:d inevitably tuned) for a single model resolution and so this issue tends not to be addressed. In ihis study, this issu...

CD40 is a member of the tumor necrosis factor receptor superfamily, expressed on a wide range of cell types including B cells, macrophages, and dendritic cells. CD40 is the receptor for CD40 ligand (CD40L), a molecule predominantly expressed by activated CD4(+) T cells. CD40/CD40L interaction induces the formation of memory B lymphocytes and promotes Ig isotype switching, as demonstrated in mic...

The authors describe the case of a 28-year-old woman, with a history of recurrent bacterial infections since childhood and multiple hospitalizations for pneumonia, with important pulmonary sequelae, including bronchiectasis which warranted the need to perform a left lobectomy and lingulectomia at age 13. After diagnostic work up, the diagnosis of hypogammaglobulinemia with hyper-IgM was establi...