BACKGROUND Although donor dopamine treatment reduces the requirement for post transplantation dialysis in renal transplant recipients, implementation of dopamine in donor management is hampered by its hemodynamic side-effects. Therefore novel dopamine derivatives lacking any hemodynamic actions and yet are more efficacious in protecting tissue from cold preservation injury are warranted. We hyp...

Research in my laboratory focuses on developing new microbial processes for adding functionality groups to plant lipids or their component fatty acids to produce value-added food and industrial products. The goal is to develop new products from surplus soybean oil or its component fatty acids through bioprocesses. Oxygenated fatty acids such as hydroxy-, keto-, epoxy-, and cyclic fatty acids ar...

French tamarisk, Tamarix gallica L. (family Tamaricaceae) is a deciduous tree that, like other halophytes, grows in wide variety of saline habitats thanks to its powerful phenolics-based antioxidant system. Given that properties are usually linked the presence compounds with antifungal properties, work presented herein antimicrobial activity T. bark extract was investigated against four phytopa...

All-nitrogenated sugars (ANSs), in which all hydroxy groups a carbohydrate are replaced with amino groups, anticipated to be privileged structures useful biological activities. In their Communication on page 5193, Takaaki Sato, Noritaka Chida, and co-workers report the synthesis, transformation, tests of ANS derivatives. The key success was seven-step synthesis ANSs by sequential Overman rearra...

Several structurally related metabolites of progesterone (3 alpha-hydroxy pregnane-20-ones) and deoxycorticosterone (3 alpha-hydroxy pregnane-21-diol-20-ones) and their 3 beta-epimers were evaluated for protective activity against pilocarpine-, kainic acid- and N-methyl-D-aspartate (NMDA)-induced seizures in mice. Steroids with the 3-hydroxy group in the alpha-position and 5-H in the alpha- or ...