It has been proposed that intervertebral disc degeneration might be caused by low-grade infection. The purpose of the present study was to assess the incidence of herpes viruses in intervertebral disc specimens from patients with lumbar disc herniation. A polymerase chain reaction based assay was applied to screen for the DNA of eight different herpes viruses in 16 patients and two controls. DN...

INTRODUCTION We present a case of an unusual clinical manifestation of Guillain-Barre syndrome following a pre-existing herpes virus infection. Although there have been several reports describing the co-existence of herpes virus infection and Guillain-Barre syndrome, we undertook a more in-depth study of the cross-reactivity between herpes viruses and recommend a follow-up study based on serolo...

    Acyclovir (9-[2-hydroxyethoxymethyl] guanine) is an acyclic nucleoside analogue of guanosine which is a potent and selective antiviral agent. Acycloviris converted to the monophosphate by thymidine kinase the virus-specific form of this enzyme and is subsequently converted to the triphosphate by the host cell kinase. Acyclovir triphosphate inhibits viral DNA-polymerase terminating the chain...

A protocol for testing cerebrospinal fluid specimens using a range of PCR assays for the diagnosis of central nervous system infection was developed and used to test prospectively 383 specimens. PCR assays were used for the detection of adenovirus, Borrelia burgdorferi, enteroviruses, Epstein Barr virus, cytomegalovirus, herpes simplex virus, human herpes virus type 6, JC virus, Leptospira inte...

Tankersley, Robert W., Jr. (Medical College of Virginia, Richmond). Amino acid requirements of herpes simplex virus in human cells. J. Bacteriol. 87:609-613. 1964.-Progressive infection of human cells minimally infected with herpes simplex virus requires 11 of the amino acids of Eagle's medium, and glutamine. Lysine is not required, but rather exerts a partially inhibitory effect upon virus mul...

background and aims: herpes simplex virus (hsv) is responsible for several significant human viral diseases, with severity ranging from subclinical to fatal infection. herpes simplex virus type 2 (hsv2) infections are more commonly seen in association with the genitalia and surrounding areas, and can be transmitted to newborns during childbirth. generalized infections in newborns are also predo...

Lymphocytopenia and CD4+ T lymphocytopenia can be associated with many bacterial, fungal, parasite and viral infections. They can also be found in autoimmune and neoplastic diseases, common variable immunodeficiency syndrome, physical, psychological and traumatic stress, malnutrition and immunosuppressive therapy. Besides, they can also be brought into relation, without a known cause, with idio...

objective herpes simplex virus (hsv), one of the most common sexually transmitted disease is a worldwide .this study aimed to prevalence of herpes simplex virus of pregnancy in iran. methods: we searched pubmed, scopus, ovid, science direct and national databases were searched: magiran, iranmedex and science information database (sid) up to october 2015.eventually, we included five studies that...

Investigations of serum antibody status to the five human herpesviruses--herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, Epstein-Barr virus, and varicella-zoster virus--were conducted on 197 Navajo children, aged 1-15 years, at a reservation pediatric outpatient clinic in Crownpoint, New Mexico, from 1981-1984. To determine the severity of infection with the human her...

Background: Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic encephalitis, with significant morbidity and mortality that are effectively reduced by antiviral treatment. Herpes simplex infection in pregnant women rarely results in encephalitis. The most common symptoms of a pregnant woman with herpes simplex infection are colds and skin vesicles. Herpetic encephalitis...