نتایج جستجو برای: human gm

تعداد نتایج: 1658424  

2017

LEUKINE (sargramostim) is a recombinant human granulocyte-macrophage colony stimulating factor (rhu GM-CSF) produced by recombinant DNA technology in a yeast (S. cerevisiae) expression system. GM-CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells. LEUKINE is a glycoprotein of 127 amino acids characterized by three primary mo...

Journal: :Current opinion in food science 2021

In recent years, human gut microbiota (GM) has emerged as a potential target to modulate health and disease. GM could be shaped by different factors, being diet one of the major influences. It metabolizes ingested nutrients produce an extensive range microbial metabolites that may have important impact on physiology. turn, dietary components composition metabolic activity GM, causing either pos...

Journal: :Journal of leukocyte biology 1989
J L Mege J Gomez-Cambronero T F Molski E L Becker R I Sha'afi

Granulocyte-macrophage colony-stimulating factor, GM-CSF, potentiates superoxide generation produced by human neutrophils stimulated with fMet-Leu-Phe and platelet-activating factor, PAF, but not by phorbol 12-myristate 13-acetate (PMA) or opsonized zymosan. The potentiation is greatest in fMet-Leu-Phe-stimulated cells. This indicates that the actions of only certain receptors are potentiated b...

Journal: :Blood 1989
L M Budel I P Touw R Delwel S C Clark B Löwenberg

Interleukin-3 (IL-3) and granulocyte-monocyte-colony-stimulating factor (GM-CSF) stimulate proliferation of human acute myeloid leukemia (AML) in vitro, although patterns of response among clinical cases are diverse. Whether regulatory abnormalities related to growth factor responses in human AML may establish the outgrowth of the neoplasm is unclear. We determined receptor numbers and affinity...

Journal: :Genomics, Society and Policy 2007

1998
Kenichi Suzuki Masayuki Hino Fumihiko Hato Noriyuki Tatsumi Seiichi Kitagawa

To clarify the differences of the signaling pathways used by granulocyte colony-stimulating factor (G-CSF), granulocytemacrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-a (TNF), we investigated activation of mitogen-activated protein kinase (MAPK) subtype cascades in human neutrophils stimulated by these cytokines. G-CSF exclusively tyrosine-phosphorylated extracellular s...

Journal: :Journal of immunology 2000
J Reibman A T Talbot Y Hsu G Ou J Jover D Nilsen M H Pillinger

GM-CSF has a major role in the immune and inflammatory milieu of the airway. Airway epithelial cells (AEC) are among the first targets of environmental stimuli and local cytokines, in response to which they can produce GM-CSF. The regulation of GM-CSF is only minimally understood in AEC. We hypothesized that GM-CSF expression in AEC would result from activation of protein kinase C (PKC) and sub...

Journal: :Molecular cancer therapeutics 2008
Leslie S Kurtzberg Traci Battle Cecile Rouleau Rebecca G Bagley Naoki Agata Min Yao Steven Schmid Stephanie Roth Jennifer Crawford Roy Krumbholz Reginald Ewesuedo Xian-Jie Yu Fei Wang Edmond J Lavoie Beverly A Teicher

Topoisomerase I (TopoI), an established anticancer target, is an enzyme producing a single-strand DNA break during transcription. Several noncamptothecin TopoI inhibitors have been identified. One of these, ARC-111, was compared with two clinically used camptothecins, topotecan and irinotecan/SN-38. In mouse and human bone marrow colony formation [colony-forming units granulocyte-macrophage (CF...

Journal: :The Journal of Cell Biology 1998
Oliver Wessely Eva-Maria Deiner Kim Chew Lim Georg Mellitzer Peter Steinlein Hartmut Beug

The cytokine Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) regulates proliferation, differentiation, and apoptosis during myelopoiesis and erythropoiesis. Structure-function relationships of GM-CSF interactions with its receptor (GM-R), the biochemistry of GM-R signal transduction, and GM-CSF action in vivo are relatively well understood. Much less is known, however, about GM-R func...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Yoshitaka Murata Akihide Tanimoto Ke-Yong Wang Masato Tsutsui Yasuyuki Sasaguri Filip De Corte Hiroshi Matsushita

OBJECTIVE To study the effect of granulocyte macrophage-colony-stimulating factor (GM-CSF) on histamine metabolism in arteriosclerosis, the expression of histidine decarboxylase (HDC; histamine-producing enzyme), histamine receptors 1 and 2 (HH1R and HH2R), and GM-CSF was investigated in human and mouse arteriosclerotic carotid arteries. Furthermore, the molecular mechanisms of GM-CSF-induced H...

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