NRF2 is a master regulator of the antioxidative response that was recently proposed as potential extracellular matrix (ECM) gene expression. Fibroblasts are major ECM producers in all connective tissues, including dermis. A better understanding NRF2-mediated regulation skin fibroblasts thus great interest for homeostasis maintenance and aging protection. In this study, we investigate impact dow...

The present study demonstrates that fibroblasts associated with carcinomas stimulate tumor progression of initiated nontumorigenic epithelial cells both in an in vivo tissue recombination system and in an in vitro coculture system. Human prostatic carcinoma-associated fibroblasts grown with initiated human prostatic epithelial cells dramatically stimulated growth and altered histology of the ep...

Systemic sclerosis (SSc) is characterized by excessive deposition of extracellular matrix (ECM) in the involved organs. Fibroblasts are activated and develop an uncontrolled synthesis collagen other ECM constituents. Previous studies have focused on cultured fibroblasts, but interpretation results been limited due to possible selection fibroblast populations. To better understand heterogeneity ...

Mesenchymal stem/stromal cells (MSCs) and fibroblasts are present in normal tissues to support tissue homeostasis. Both share common pathways have a number of features, such as spindle-shaped morphology, connective localization, multipotency. In inflammation, nonspecific response injury, MSC the main players. Two mechanisms their mode action been defined: immunomodulation regeneration. Followin...

The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects by allowing for passage oxygen nutrients, while at same time preventing pathogens toxins. BBB also prevents efficient delivery drugs to brain, e.g. treatment tumors. In murine perivascular fibroblasts were recently identified as a novel potential constituent BBB. Her...

Programmed cell death (apoptosis) is an active process by which cells initiate their own self-destruction. Growing evidence shows that this event is controlled by the activation of unique gene expressions; some function as survival genes, such as bell, and others as killer genes, such as cedi or interleukin converting enzyme. Likewise, external factors, such as the presence or absence of stimul...