objective(s): our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125i]pyk) is promising for the evaluation of the epidermal growth factor receptor (egfr) status and prediction of gefitinib treatment of non-small cell lung cancer. egfr is over-expressed and mutated also in glioblastoma. in the present study,...

egfr is a key molecule in cancer cells. egfr signaling was shown to promote tumor cell proliferation and survival, invasion and angiogenesis and mediate resistance to treatment, including ionizing radiation in preclinical models. we extracted proteins from astrocytoma (iii and iv) oligodendroglioma(iv) tumors and normal brain tissues and then evaluated the protein purity by bradford test and sp...

Signalling through protein tyrosine kinases (PTKs) is critical in the regulation of important cellular processes and its deregulation is associated with pathophysiological disorders such as cancer. We investigated the function of the PTK spleen tyrosine kinase (Syk) in the regulation of growth factor signalling pathways in human mammary epithelial cells. Our results show that downregulation of ...

In this issue of Journal of Clinical Oncology, Baehner et al have reported from a Kaiser Permanente case-control study that there is a high degree of concordance (97%) between quantitative reverse transcription polymerase chain reaction (qRT-PCR) and central laboratory fluorescent in situ hybridization (FISH) assessment of HER2 status. This provides us the opportunity to examine the status of h...

ABSTRSCT: The advent of human epidermal growth factor receptor-2 (HER2) Status and biomarker testing has modified the treatment and prognosis of gastric, breast and colorectal cancer. Epidermal growth factor receptor and HER-2 family maneuvers a key role in the exploitation of gastric cancer by detecting the epidermis express in gastric cancer tissue and to investigate serum and tissue HER2. Ta...

The prognosis of patients with human epidermal growth factor receptor-2 (HER2)-overexpressed metastatic breast cancer (MBC) has improved drastically following the development anti-HER2 therapies. We question what factors are involved in outcome by treatment. One hundred and two MBC who received chemotherapy were classified into groups according to subtype: luminal/HER2-negative (n = 50), HER2 2...

Lung adenocarcinoma is the most common subtype of non-small cell lung cancer (NSCLC). With the discovery of epidermal growth factor receptor (EGFR) mutations, anaplastic lymphoma kinase (ALK) rearrangements, and effective targeted therapies, therapeutic options are expanding for patients with lung adenocarcinoma. Here, we review novel therapies in non-squamous NSCLC, which are directed against ...