OBJECTIVES Acute hypercalcemia is a serious condition and represents a physician-surgical emergency: the difficulty in setting a precise diagnosis is due to several possibilities that can cause the condition. It is our purpose to critically evaluate the most actual schemes of treatment and the conditions that could favour the appearance of a hypercalcemic acute crisis. MATERIALS AND METHODS A...

Mutations of the HRPT2 gene, which are responsible for hyperparathyroidism-jaw tumor (HPT-JT) syndrome, have been implicated in the development of a high proportion of parathyroid carcinomas. The aim of this study was to investigate differences in expression of the most important genes connected with parathyroid carcinoma between HPT-JT syndrome due to an HRPT2 splicing mutation, normal parathy...

Modern computer systems feature multiple homogeneous or heterogeneous computing units with deep memory hierarchies, and expect a high degree of thread-level parallelism from the software. Exploitation of data locality is critical to achieving scalable parallelism, but adds a significant dimension of complexity to performance optimization of parallel programs. This is especially true for program...

The deprotonation constants of 5-hydroxy-5,6-di-pyridin-2-yl-4,5-dihydro-2H-[1,2,4] triazine-3-thione (HPT) and the stability constants of its Hg , Ni , Cu , Pb , and Zn ion complexes were studied in 20% ethanol and water mixed at 25 ± 0.1 ◦C and ionic strength (I) of 0.1 M supported by NaCl. Four pKa values of HPT were determined: 3.58, 6.30, 9.23, and 9.69. In various pH conditions, the diffe...

Objective . This study aims to highlight the challenges in the diagnosis of hyperparathyroidism (HPT) in patients with advanced chronic kidney disease (CKD). Methods . In this report, we describe a middle-aged Filipino gentleman with underlying CKD who presented with intractable nausea, vomiting, severe and medically refractory hypercalcaemia and parathyroid hormone (PTH) concentrations in exce...

An investigation was initiated to examine the effect of rotation speed on the allotropic α to ω-phase transformation in titanium. A grade 2 commercial purity titanium was processed by high-pressure torsion (HPT) at room temperature up to a maximum of 10 turns using a pressure of 5.0 GPa and different rotation speeds from 0.5 to 2 rpm. It is shown that the allotropic phase transformation occurs ...

OBJECTIVE The aim of this study was to further elucidate the mechanisms of dual-phase technetium-99m methoxyisobutylisonitrile (Tc-MIBI) parathyroid imaging by exploring the association between early uptake results (EUR), delayed uptake results (DUR), and the retention index (RI) in dual-phase Tc-MIBI parathyroid imaging and P glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1...

The influence of secondary hyperparathyroidism (2 HPT) on the set point of the parathyroid hormone (PTH)-Ca(2+) curve is controversial. In vitro experiments have shown an increase in the set point. However, clinical studies with hemodialysis patients have provided a variety of results (increases, decreases and no changes in the set point have been reported). The present study was designed to in...

BACKGROUND Perchlorate (ClO4(-)) is an environmental contaminant known to disrupt the thyroid axis of many terrestrial and aquatic species. ClO4(-) competitively inhibits iodide uptake into the thyroid at the sodium/iodide symporter and disrupts hypothalamic-pituitary-thyroid (HPT) axis homeostasis in rodents. OBJECTIVE We evaluated the proposed mode of action for ClO4(-)-induced rat HPT axis...

X-linked hypophosphatemic rickets (XLH) is a dominant disorder characterized by hypophosphatemia due to impaired renal tubular reabsorption of inorganic phosphate. Cardinal manifestations include defective calcification of cartilage and bone, growth retardation and resistance to phosphorus and vitamin D therapy. Although secondary hyperparathyroidism (HPT) is a common complication of treatment,...