In this present research work, we have designed a pulsincap formulation comprising mini-tablets, which to the best of our knowledge this combination has not been reported yet. We successfully combined the advantages of mini-tablets technology to meet the optimized requirements of our pulsincap formulation. Our main aim was to target lornoxicam to treat rheumatoid arthritis as per the chronother...

Tizanidine hydrochloride is an orally administered prokinetic agent that facilitates or restores motility through-out the length of the gastrointestinal tract. The objective of the present investigation was to develop effervescent floating matrix tablets of tizanidine hydrochloride for prolongation of gastric residence time in order to overcome its low bioavailability (34-40 %) and short biolog...

The aspire of this attempt was to design and evaluate aceclofenac loaded sustained release microspheres by emulsion solvent evaporation method, using different polymers like Ethyl cellulose (EC), Kollidon SR (KSR), Eudragit RS 100, Eudragit RL 100 and Hydroxypropylmethyl Cellulose (HPMC K100M). Microspheres were prepared using different stirring rate (1200, 1500, 2000rpm) and larger microsphere...

Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of medications that are characterized by a narrow absorption window. A new strategy is proposed for the development of gastroretentive dosage forms for ofloxacin preferably once daily. The design of the delivery sy...

The objective of the study is to formulate bilayer tablets consisting of atorvastatin calcium (AT) as an immediate release layer and nicotinic acid (NA) as an extended release layer. The immediate release layer was prepared using super disintegrant croscarmellose sodium and extended release layer using hydroxypropylmethyl cellulose (HPMC K100M). Both the matrix and bilayer tablets were evaluate...

Abstract: Objectives: Stavudine has a low half-life of 0.8-1.5 hr and therefore needs recurrent administration to sustain stable beneficial drug plasma levels. In order enhance preserve the level stavudine for round clock, gastroretentive systems (floating low-density formulations that cause buoyancy on gastric fluid in stomach) may prove be advantageous releasing content from matrix tablet res...

Purpose: To comparatively evaluate the effect of two hydroxylpropyl methylcellulose (HPMC) molecular weight grades (K4M and K15M) on drug release from diclofenac sodium matrix tablets. Methods: Tablets containing diclofenac sodium were prepared by direct compression method at various drug/HPMC ratios and evaluated in vitro for their water uptake, erosion and dissolution characteristics over a p...

INTRODUCTION The percolation theory studies the critical points or percolation thresholds of the system, where one component of the system undergoes a geometrical phase transition, starting to connect the whole system.The application of this theory to study the release rate of hydrophilic matrices allows to explain the changes in release kinetics of swellable matrix type system and results in a...

The influence of polyvinylpyrrolidone (PVP), a commonly used binder and adhesive, on the aggregation of spheroids coated with hydroxypropylmethylcellulose (HPMC) was studied. The aggregation propensities of spheroids coated by HPMC alone and by HPMC with polyethylene glycol (PEG) were compared with those coated by HPMC with PVP and the viscosity of the coating solutions determined. The coating ...

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subject...