Malaria transmission intensity is highly heterogeneous even at a very small scale. Implementing targeted intervention in malaria transmission hotspots offers the potential to reduce the burden of disease both locally and in adjacent areas. Transmission of malaria parasites from man to mosquito requires the production of gametocyte stage parasites. Cluster analysis of a 19-year long cohort study...

Accident hotspots, locations where accidents are historically concentrated, contribute significantly to road traffic accidents being the leading cause of death by injury. A notable improvement in driver safety can be achieved through warnings of known upcoming hazardous features. However, as installing and maintaining traditional road sign infrastructure can be costly, warnings on accident hots...

Concentrations of four heavy metals (Cr, Cu, Ni, and Zn) were measured at 1,082 sampling sites in Changhua county of central Taiwan. A hazard zone is defined in the study as a place where the content of each heavy metal exceeds the corresponding control standard. This study examines the use of spatial analysis for identifying multiple soil pollution hotspots in the study area. In a preliminary ...

In most organisms, including humans, meiotic recombination occurs preferentially at a limited number of sites in the genome known as hotspots. There has been substantial progress recently in elucidating the factors determining the location of meiotic recombination hotspots, and it is becoming clear that simple sequence motifs play a significant role. In S. pombe, there are at least five unique ...

Hotspots represent transient but highly congested regions in wireless ad hoc networks that result in increased packet loss, end-to-end delay, and out-of-order packets delivery. We present a simple, effective, and scalable hotspot mitigation protocol (HMP) where mobile nodes independently monitor local buffer occupancy, packet loss, and MAC contention and delay conditions, and take local actions...

Crime prediction is a topic of significant research across the fields of criminology, data mining, city planning, law enforcement, and political science. Crime patterns exist on a spatial level; these patterns can be grouped geographically by physical location, and analyzed contextually based on the region in which crime occurs. This paper proposes a mechanism to parameterize street-level crime...

This research advances the understanding of the location of perceived landscape values through a statistically based approach to spatial analysis of value densities. Survey data were obtained from a sample of people living in and using the Murray River region, Australia, where declining environmental quality prompted a reevaluation of its conservation status. When densities of 12 perceived land...

One primary goal of gene network analysis is to identify key regulatory components, or key drivers, of sub-networks with respect to various biological contexts. Here we developed a general algorithm to identify key drivers in gene regulatory networks. The generalized key driver analysis (KDA) uncovers not only the well-known regulators for the expression quantitative trait locus (eQTL) hotspots...

Hotspot analysis is the identification and ranking of countries or other geographic regions on the basis of biodiversity. Hotspots have exceptional biodiversity per unit land area. This paper introduces a new method of hotspot analysis that ranks hotspots on the basis of biodiversity and anthropogenic threats to biodiversity. These threats are represented by socioeconomic factors such as human ...

Recombination clusters nonuniformly across mammalian genomes at discrete genomic loci referred to as recombination hotspots. Despite their ubiquitous presence, individual hotspots rapidly lose their activities, and the molecular and evolutionary mechanisms underlying such frequent hotspot turnovers (the so-called "recombination hotspot paradox") remain unresolved. Even though some sequence moti...