نتایج جستجو برای: hotspot analysis
تعداد نتایج: 2829932 فیلتر نتایج به سال:
Most mutations in cancer are rare, which complicates the identification of therapeutically significant mutations and thus limits the clinical impact of genomic profiling in patients with cancer. Here, we analyzed 24,592 cancers including 10,336 prospectively sequenced patients with advanced disease to identify mutant residues arising more frequently than expected in the absence of selection. We...
Infrared thermography technology is currently being used in various applications, including fault diagnosis in electrical equipment. Thermal abnormalities are diagnosed by identifying and classifying the hotspot conditions of electrical components. In this article, a new recursively constructed outputcontext fuzzy system is proposed to characterize the condition of electrical hotspots. An infra...
Smoking is the major risk factor for lung squamous cell carcinoma (SCC), although a small number of lung SCCs occurs in never-smokers. The purpose of this study was to compare 50 hotspot mutations of lung SCCs between never-smokers and smokers. We retrospectively reviewed the medical records of patients newly diagnosed with lung SCC between January 1, 2011 and December 31, 2013 in the Seoul Nat...
A major challenge in Spoken Dialogue Systems (SDS) is the detection of problematic communication (hotspots), as well as the classification of these hotspots into different types (root cause analysis). In this work, we focus on two classes of root cause, namely, erroneous speech recognition vs. other (e.g., dialogue strategy). Specifically, we propose an automatic algorithm for detecting hotspot...
The importance of high-incidence "hotspots" to population-level tuberculosis (TB) incidence remains poorly understood. TB incidence varies widely across countries, but within smaller geographic areas (e.g., cities), TB transmission may be more homogeneous than other infectious diseases. We constructed a steady-state compartmental model of TB in Rio de Janeiro, replicating nine epidemiological v...
The growth of intelligence-led policing has placed even greater emphasis on the clear identification of crime hotspots as well as the choice of the crime reduction or detection strategy identified to combat a problem. Crime hotspots are becoming central to policing strategy in many locations, as they enable an operational commander to focus resources into the areas of highest need. This paper o...
The procaryotic transposon Tn5 inserts into many different sites within a single gene, but some sites (hotspots) are targeted repeatedly. Hotspots are not closely related in sequence, but most have G/C pairs at the ends of the nine base pairs duplicated by Tn5 insertion. In pBR322, the major hotspot coincides with the "-10 region" of the tet promoter. We mutated the G/C pairs at this hotspot an...
Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing
AIM To study cancer hotspot mutations by next-generation sequencing (NGS) in stool DNA from patients with different gastrointestinal tract (GIT) neoplasms. METHODS Stool samples were collected from 87 Finnish patients diagnosed with various gastric and colorectal neoplasms, including benign tumors, and from 14 healthy controls. DNA was isolated from stools by using the PSP® Spin Stool DNA Plu...
Homologous recombination hotspots increase the frequency of recombination in nearby DNA. The M26 hotspot in the ade6 gene of Schizosaccharomyces pombe is a meiotic hotspot with a discrete, cis-acting nucleotide sequence (5'-ATGACGT-3') defined by extensive mutagenesis. A heterodimeric M26 DNA binding protein, composed of subunits Mts1 and Mts2, has been identified and purified 40,000-fold. Clon...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید