Purpose: Fast-release gastroretentive solid dispersions of glibenclamide using gelucire were prepared to achieve improved bioavailability. Methods: Hot melt granulation technique was adopted to prepare solid dispersions (SDs) of glibenclamide in gelucire 50/13 and were compared with pure glibenclamide and physical mixtures of drug and gelucire using hot stage polarized microscopy, powder x-ray ...

Continental flood basalt eruptions have resulted in sudden and massive accumulations of basaltic lavas in excess of any contemporary volcanic processes. The largest flood basalt events mark the earliest volcanic activity of many major hot spots, which are thought to result from deep mantle plumes. The relative volumes of melt and eruption rates of flood basalts and hot spots as well as their te...